| 李承珠,杨诗春,赵凤娣,杨轶群.益母草、赤芍、当归、三棱、莪术、泽兰对大白鼠血液凝固作用的影响[J].,1982,(2):111-112,69 |
| 益母草、赤芍、当归、三棱、莪术、泽兰对大白鼠血液凝固作用的影响 |
| The Influence of Yimucao,Chishao,Danggui,Santeng,Erzhu and Zelan upon the Blood Coagulation of Rats |
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| DOI： |
| 中文关键词: 益母草 大白鼠 血小板计数 体外血栓形成 血小板聚集功能 优球蛋白溶解时间 当归 凝固作用 白陶土部分凝血活酶时间 三棱 |
| 英文关键词: |
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| 中文摘要: |
| 益母草、赤芍、当归、三棱、莪术、泽兰是临床常用的活血化瘀药。这些药物对于血液凝固作用的影响,近年有所报道,但限于体外血栓形成、血小板聚集、凝血酶时间等几个指标,多数采用离体和动物静脉给药的方法。为了更全面地了解这些活血化瘀药对血液凝固的影响,并使给药方法更接近于中医的传统,我们通过胃饲中药煎剂,观察 |
| 英文摘要: |
| Malerats weighing 200±50 gm each were fed with 6-8 ml of testing herb decoctions twice at an interval of 1(1/2)hours,after 14-15 hours of fasting.The total amount of decoction given to one rat corresponded to 15-20 gm of crude drugs.Instead of decoction,fresh water was used in control animals.At 1(1/2)to 2 hours after the second feed the rats’ blood was let out from the carotid artery under methane for the determination of the coagulative function and the fibrinolytic activity in comparison with those of the control group.The results were as follows:(1)Yimucao,Danggui,Chishao,Sanleng and Erzhu prolonged the time for torombus formation in vitro,shortened the length of thrombus and decreased the weight(both dry and wet)of thrombus, while Zelan lessvned the dry weight only.(2)Yimucao,Danggui,Sanleng and Erzhu decreased the platelet count and lowered the platelet aggregation function,While Chishao and Zelan had no effect on the platelet count but inhibited the aggregation function.(3)Yimucao,Danggui,Chishao and Sanleng prolonged the prothrombin time as well as the partial throm boplastin time,i.e.both the extrinsic and the intrinsic coagulation systems were inhibited,while Zelan prolonged only the partial thromhoplastin time,i.e.the intrinsic system was invovled.There was no effect on the coagulation system was invovled.There was no effect on the coagulation system in the case of Erzhu.(4)The serum fibrinogen level was decreased by Yimucao and the euglobulinlysis time was shortened by Yimucao,Chishao and Sanleng,which indicated that fibrinolysis was promoted by these drugs. Yimucao(益母草)motherwort,Leonurus heterophyllus Sweet.Chishao(赤芍)Paeonia lactiflora Pall.Danggui(当归) Angelica sinensis(Oliv.)Diels.Sanleng(三棱)Spargonium stiloniferum Buch-Ham.Erzhu(莪艹术)Curcuma zedoaria(Berg.) Rosc.Zelan(泽兰)Lycopus lucidus Turcz. |
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