| 李恩,赵玉庸,谢惠芬,李寿龄,张贵印,王吉匀,赵梅,李琳琳,王辅才,张家祺,胡晓东,马家驹,田乃庚,马新云.肾性高血压中医分型与血浆前列腺素、肾素、血管紧张素Ⅱ、环核苷酸变化的观察[J].,1983,(3):165-167,132 |
| 肾性高血压中医分型与血浆前列腺素、肾素、血管紧张素Ⅱ、环核苷酸变化的观察 |
| TCM Typology of Renal Hypertension and Changes of PG,Renin,Angiotensin Ⅱ,Cyclic Nucleotide in Plasma |
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| DOI： |
| 中文关键词: 前列腺素 血管紧张素 肾性高血压 阴阳两虚 肾素活性 高血压患者 滋补肝肾 肾阴虚 血浆 慢性肾炎 |
| 英文关键词: |
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| 中文摘要: |
| 慢性肾炎高血压型是目前治疗中研究的难题之一。为了进一步探讨肾性高血压的机理,我们对42例肾性高血压患者根据中医的辨证,分为肾阴虚、肾阳虚和阴阳两虚三组。分别测定了血浆中前列腺素（PGA2、PGE1、PGF2α）. |
| 英文摘要: |
| The treatment of chronic glomerulonephritis type of hypertension is now still a problem.According to the differentiation of symptom-complexes,the content or activity of PG(PGA2,PGE1,PGF2α)renin,angiotensin Ⅱ, and cyclic nucleotide（cAMP,cGMP）in plasma were measured respectively for the deficiency of Yin（vital essence）of the kidney,the deficiency of Yang（vital function） of the kidney and the deficiency of both Yin and Yang in 42 cases with renal hypertension.At the same time,the determination of sodium and potassium content in urine for 24 hours has also been carried out,and the relationship between the changes of these indications and the typology of TCM observed.17 cases of them were treated with the method of activating the blood circulation to eliminate blood stasis and tonify the liver and kidney,the results of which were compared with the above indications to investigate the mechanism of lowering hypertension with such method of treatment.The clinical study has shown:1.Most cases of renal hypertension are of the deficiency of Yin type on the basis of TCM differentiation of symptom-complexes.2.In the groups of deficiency of Yin and deficiency of both Yin and Yang of renal hypertension,increase in PG, particularly the PGF2αpresents direct proportion with renin.3.In the group of deficiency of Yin and yang,PGE1 andPGE2αboth exhibit direct proportion with cAMP.4.In the above group,the activity changes of renin display inverse proportion with the excretion of sodium in urine for 24 hours.5.Compared with the deficiency of Yin group, angiotensin Ⅱ in the deficiency of Yin and Yang group increases singnificantly.6.Good results have been observed in 17 patients with renal hypertension treated by activating the blood circulation to eliminate blood stasis and tonify the liver and kidney.This method of treatment may improve the blood circulation of kidney and promote the synthesis and release of PGA2 and PGE1. |
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