Quick Search:         Advanced Search
Chinese Version
Online office
Journal Online
Download
Top
Links
李承珠,杨诗春,赵凤娣,杨轶群,杨春欣,张德成.丹参素抗凝血作用的研究[J].,1983,(5):297-299,260
丹参素抗凝血作用的研究
Experimental Study on the Anticoagulative Action of Danshensu
  
DOI:
中文关键词:  丹参素  抗凝血作用  丹参注射液  血小板聚集功能  血小板计数  静脉注射  体外血栓形成  大白鼠  优球蛋白溶解时间  自身对照
英文关键词:
基金项目:
Author NameAffiliation
Li Chengzhu 上海第一医学院基础医学部病理生理教研室 
杨诗春 上海第一医学院基础医学部病理生理教研室 
赵凤娣 上海第一医学院基础医学部病理生理教研室 
杨轶群 上海第一医学院基础医学部病理生理教研室 
杨春欣 中山医院药剂室 
张德成 上海第一医学院药学系天然药化教研室 
Hits: 1669
Download times: 1394
中文摘要:
      中药丹参(Radix Salviae Milliorrhizae)抗凝血作用的有效成分迄今尚未肯定。我院药学系从正品丹参分离出多种不同成份——丹参182、丹参183、丹参186、丹参187、丹参188、丹参189。我们通过大白鼠静脉注射前、后自身对照方法,初步观察了它们对正常大白鼠凝血象的影响,发现其中只有丹参182(现称丹参素),结构式为:
英文摘要:
      Danshensu(丹参素),a water soluble monomer separated from Radix Salviae Miltiorrhizae(RSM)is one of the main components of RSM injection on sale.In experiment on rabbits,Danshensu proved to be effective against thrombus formation in vitro,platelet aggregation(ADP induced)and intrinsic or extrinsic coagulation.It caused a decrease in platelet count and hastened fibrinolysis.These actions reached a peak 30 min after i.v.injection of 20 mg/kg and lasted about an hour.These effects recovered gradually to normal 4.5 hrs after injection except the thrombus formation test.
View Full Text  View/Add Comment  Download reader