| 柴枝楠,廖家桢,傅湘琦,赵天德.参芪注射液对血小板表面活性和超微结构的影响[J].,1984,(8):484-485,452 |
| 参芪注射液对血小板表面活性和超微结构的影响 |
| Effects of Codonopsis Pilosulae-Astragalus Injection on Superficial Activity and Ultrastructure of Platelets |
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| 中文关键词: 抑制血小板聚集 心气虚 表面活性 血小板超微结构 冠心病 抑制作用 聚集数 电镜观察 家兔 表面形态 |
| 英文关键词: |
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| 中文摘要: |
| 本文应用电镜观察了一次静脉注射参芪液60ml 前后对冠心病心气虚患者血小板聚集的影响。结果提示用药前冠心病心气虚患者与正常相比血小板扩聚型和聚集数都明显增加,用药后一小时上述异常现象明显好转。用家兔血小板体外实验表明参芪液对ADP 诱导的血小板聚集也有抑制作用。血小板超微结构的初步观察提示对血小板的伪足形成及颗粒释放也可能有一定抑制作用。 |
| 英文摘要: |
| Codonopsis Pilosulae and Astragalue(CP-A)are often used to treat coronary heart disease(CHD) in TCM.In order to investigate the effects of CP-A on platelet,the present study reports the effects of CP-A on the superficial activity and ultrastructure of platelets by means of electromicroscopy.The study was performed in patients with CHD in vivo(N=9),in which the superficial activity of platelets were lowered following a single dose of 60 ml CP-A injection(content of CP-A 30gm each) intravenously.The spread type platelets and number of aggregated platelets were reduced from 27.3±4.3% to 10.8±2.9%(M±SE,P<0.01)66.9±9.6 to 24.6±6.1(M±SE,P<0.01)respectively.The results of study performed in rabbits in vitro showed that the ADP-induced platelet aggregation was also inhibited by CP-A,the spread type platelets and the number of aggregated platelets were reduced from 22.0±2.9% to 9.0±2.1%(P<0.01),55.8±9.1 to 20.2±2.9(P<0.01)respectively.The observation of changes in the ultrastructure of aggregated platelets induced by ADP found that the formation of pseudopodias and the release of α-granules and dense-granules from these platelets were inhibited by CP-A to certain extent.It is well known that adhesion,release and aggregation of platelets play an important pathogenetic role in CHD,so that the effects of CP-A on platelet is of beneficial therapeutic value for treating CHD. |
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