| 林有矞,陈玉生,韩新民,顾祖敏,景沛,莫启忠.温阳药对下丘脑—垂体—肾上腺皮质轴受抑大鼠模型的子宫雌激素受体的作用[J].,1985,(3):175-177,133 |
| 温阳药对下丘脑—垂体—肾上腺皮质轴受抑大鼠模型的子宫雌激素受体的作用 |
| The Effect of Yang Tonics on the Uterine Estrogen Receptors in Depressed Hypothalamus-Pituitary-Adrenal Cortex Axis Rats |
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| 中文关键词: 肾上腺皮质轴 温阳药 雌激素受体 血浆皮质酮 下丘脑 血浆雌二醇 模型组 大鼠子宫 垂体 大鼠模型 |
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| 中文摘要: |
| 本文观察了温阳药对下丘脑—垂体—肾上腺皮质轴受抑大鼠模型的血浆皮质酮、血浆雌二醇和雌激素受体(简称 E-R)的影响。实验显示模型组大鼠血浆皮质酮及子宫胞浆中 E-R 含量降低,而温阳药治疗则使血浆皮质酮和血浆雌二醇明显增高,使子宫 E-R含量增加,接近正常水平,且提高了雌二醇和 E-R 的亲和力。说明温阳药对下丘脑—垂体—肾上腺皮质轴受抑大鼠的子宫 E-R 改变具有保护和治疗作用。 |
| 英文摘要: |
| The authors studied the change in uterine estrogen receptors(E-R)of dexamethasone-induced depressed hypothalamus-pituitary-adrenal cortex axis rats and the effect of Yang tonics on it. Female Wistar rats,weighing 250g each,during sexual quiescent stage were chosen and divided randomly into 3 groups:(1)Controls(C),with 4ml of normal saline instilled into the stomach daily;(2)models(M),with 2ml of dexamethasone suspension and 2ml of normal saline instilled daily;and(3)treated(T)animals,with 2ml of dexamethasone suspension and 2ml of Yang tonics instilled daily instead.The aniamls were exsanguinated up to death on the 18th day,and their uteri removed promptly.Blood samples were taken for plasma cortisone and estradiol estimation.Uterine cytoplasmic homogennates were prepared under 0～4℃ and their E-R values estimated with DCC method. The result of the experiment showed that all of the animals in M group developed bowed(arched)back,had a mean drop in body weight of 33g and a marked decrease in plasma cortisone as compared with the controls(P <0.001).This denoted an inhibition(depression)of hypothalamus-pituitary-adrenal cortex axis and establishment of the animal model. The E-R contents of the three groups C,M and T of animals were 166±11.9,136±6.7 and 156±6.9(M±SE) fmol/ng protein respectively;that in M group wassignificantly lower than in C group(P<0.05).Yang tonics had been shown to have protective and also therapeutic effects in the reversal of such changes,which increased the E-R contents of the uterine cytoplasm and enhanced the affinity of estradiol to E-R.According to the authors the increase of E-R content in the treated animals might be the result of the action of Yang tonics. |
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