| 汪承柏,常爱敏,宋为云,韩俊英,葛安平,陈德永,生翠娟.凉血活血重用赤芍治疗重度黄疸肝炎血浆血栓素B2变化的研究——附6例报告[J].,1985,(6):326-328,355,322 |
| 凉血活血重用赤芍治疗重度黄疸肝炎血浆血栓素B2变化的研究——附6例报告 |
| A Study of the Plasma Thromboxane B2 Changes in Severe Icteric Hepatitis Treated by Dispelling the Pathogenic Heat from Blood,Promoting Blood Circulation and Administrating Heavy Dosages of Radix Paeoniae—6 Case Reports |
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| 中文关键词: 内毒素血症 凉血活血 重度黄疸肝炎 血浆血栓素 抑制血小板聚集 治疗前后 前后比较 赤芍 肝硬化腹水 血清总胆红素 |
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| 中文摘要: |
| 本文报道用凉血活血重用赤芍治疗6例重度黄疸肝炎,治疗前后用放射免疫法测定了血浆血栓素 B2（TXB2）,治疗前血清总胆红素及 TXB2均值为30.15±9.97mg%及512±158.43pg/ml,黄疸基本消退后 TXB2均值为85.48±37.34pg/ml,治疗前后比较 t=6.33,P<0.001。本研究有助于阐明本治法作用机理并旁及其他 TXB2升高疾病的治疗研究。 |
| 英文摘要: |
| This paper preserits the Thromboxane B2（TXB2）changes in the 6 patients with severe icteric hepatitis before and after their treatment by dispelling the pathogenic heat from blood,promoting blood circulation and administrating heavy dosages of Radix Paeoniae.These Cases were finally diagnosed as acute cholestatic hepatitis（4 cases）and chronic active hepatitis with deeply jaundice（2 cases）according to the results of clinical,biochemical and pathological examinations respectively.When TXB2 was measured before treatment,the average value of serum total bilirubin（STB）and TXB2 is 30.15±9.97 mg% and 512±158.43 pg/ml（the latter was measured by radioimmunoassay and its normal value is 127±48.pg/ml）.After treatment,the STB value of 2 cases returns to normal and that of the other 4 cases is 2.8,1.9,2.1,an.d 2.8 mg% respectively,and their TXB2 value is 85.48±57.34 pg/ml.The difference in TXB2 value before and after treatment is very significant.The following is our conclusion:（1） the possible mechanism of TXB2 increase in theabove-mentioned cases is that injuries in the wails of the liver vessels caused by endotoxemia and the liver disease itself lead to an increase of TXB2 due to the aggregation of platelets;（2） as a result of the disorder of microcirculation,the damage of hepatic cells and the dysfunction of capillaries caused by TXB2,the jaundice keeps increasing or remains at the same level;（3）this study is useful not only for explaining the acting mechanism of dispelling the pathogenic heat from blood,promoting blood circulation and administrating heavy dosages of Radix Paeoniae in the treatment ofsevere icteric hepatitis,but also for explaining the mechanism of promoting blood circulation to remove blood stasis and its effects in treating other disease with an increase of TXB2. |
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