| 李新吾,张克纯,唐荣德,徐桂香,黄迪南,贺石林,杨钖平.归红液对兔内毒素血症血清溶酶水平影响的观察[J].,1985,(9):558-560,516,517 |
| 归红液对兔内毒素血症血清溶酶水平影响的观察 |
| Influences of Angelica Sinensis and Carthamus Tinctorius Mixture on Serum Lysosomal Enzymes in Rabbits with Eudotoxemia |
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| DOI： |
| 中文关键词: 内毒素血症 葡萄糖醛酸酶 组织蛋白酶 红液 生理盐水 红花 当归液 溶酶体 酶活性 协同作用 |
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| 中文摘要: |
| 本文采用生理盐水对照的方法,肯定了归红液(当归、红花组成)阻遏兔内毒素血症血中β-葡萄糖醛酸酶和组织蛋白酶 D 的升高作用。单味当归和单味红花也有同样作用,但弱于归红液,提示归红液阻遏内毒素血症时,血中溶酶的升高可能是当归和红花的协同作用。 |
| 英文摘要: |
| Using serum β-glucuronidase and cathepsin D activity as indices,the changes of both enzymes during endotoxemia and the effects of Angelica sinensis and Carthamus tinctoriusand their mixture on their activity levels were observed. The experiment was carried out in two groups:normal saline group(18 rabbits and mixture of Angelica sinensis and Carthamus tinotorius(AC group)(16 rabbits).The serum lysosomat enzyme levels were determined. before and 6 hours after endotoxin administration respectively.In normal saline group and AC group,serum β- glucuronidase activity was found to be 31 and 29 units,cathepsin D activity 4.5 and 4.2 units respectively before endotoxin injection,the difference being of no statistical significance(P>0.5).But 6 hours after endotoxin injection, β-glucuronidase and cathepsin D activity were elevated to 62.5 units and 7.1 units in normal saline group and 31.6 units and 4.8 units in AC group respectively,the difference between the two groups is significant.The effect of Angelica sinensis or Carthamus tinctorius on lysosome enzymes was similar to but weaker than that of AC.These data suggest that the elevation of lysosomal enzymes during endotoxemia could be inhibited by AC and this inhibition couldbe caused by the synergy of Angelica sinensisand Carthamus tinctorius. |
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