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Author Name	Affiliation
Shen Weitang	上海第一医学院儿科医院
高玉娥	上海第一医学院儿科医院
徐凤飞	上海第一医学院儿科医院
段恕诚	上海第一医学院儿科医院
袁曼	上海第一医学院华山医院
童华华	上海第一医学院华山医院
徐肇玥	上海第一医学院华山医院
戴自英	上海第一医学院华山医院

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中文摘要:

血清β-葡萄糖醛酸苷酶活力的高低,可反映组织细胞受损的程度。本组实验动物注射内毒素造成休克后,血清β-葡萄糖醛酸苷酶活力升高明显,且随着休克时间延长,活力增高愈为明显。654-2(山莨菪碱)治疗组动物β-葡萄糖醛酸苷酶活力增高幅度较小,此结果提示654-2具有明显的抗休克作用。

英文摘要:

The effect of anisodamine on serum β-glucuronidase activity in shock is reported.It was well established that serum level of β-glucuronidase increased under various states of shock and the changes of this enzyme in serum could reflect the degree of cellular damage. Experiments were carried out on mongrel dogs in shock produced by injected endotoxin.Obvious rise in serum level of β-glucuronidase was observed.The longer the shock lasted,the higher did β-glucuronidase activity become. Our results showed that the level of serum β-glucuronidase activity was lower in the group treated with anisodamine than in the shock group. The results obtained in the present study indicate that anisodamine can improve cellular damage by way of relieving vasoconstriction and improving microcirculation.Other mechanisms remain to be elucidated.

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