| 刘耕陶,徐靭柳.冬虫夏草的免疫药理作用[J].,1985,(10):622-624,637,581 |
| 冬虫夏草的免疫药理作用 |
| Immuno-Pharmacologic Activity of Cordyceps Sinensis(Berk)Sacc |
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| DOI： |
| 中文关键词: 冬虫夏草 玫瑰花结形成 强的松龙 小鼠脾脏 脾淋巴细胞增殖 胸腺重 生物合成 腹腔注射 皮下注射 胸腺萎缩 |
| 英文关键词: |
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| 中文摘要: |
| 以冬虫夏草60%乙醇提取物予615小鼠腹腔及皮下注射,能使脾脏重量及其核酸和蛋白质的含量显著增加,并能促进脾脏 DNA 的生物合成及脾淋巴细胞的增殖,提高脾淋巴细胞 E-玫瑰花结形成率,但对 EAC-玫瑰花结形成率及溶血素的生成无明显影响。另外,冬虫夏草能明显拮抗强的松龙及环磷酰胺引起的脾脏重量减轻及脾淋巴细胞 E-玫瑰花结形成率的减少。以上结果表明,冬虫夏草对细胞免疫有促进作用,而其有效成分主要存在于冬虫夏草的子座部分。此外,冬虫夏草尚能引起小鼠胸腺萎缩,但该作用是通过肾上腺皮质实现的。 |
| 英文摘要: |
| The alcoholic-water extract of Cordyceps Sinensis(CS)was shown to induce spleen enlargement and thymus atrophy in 615 male mice.A significant increase of DNA,RNA and protein contents in the enlarged spleens were also demonstrated.The incorporation of ~3H-thymidine into spleen DNA in vivo and the proliferation of spleen cells cultivated in vitro were enhanced by the administration of CS.Moreover,CS stimulated E-Rossette forming rate but had no effect on EAC-Rossette forming rate of the spleen cells.CS counteracted the inhibition of spleen sizeand E- Rossette forming rate of the spleen cells by prednisolone and cyclophosphamide in all the mice.In addition,the extract of the strom of Cordyceps induced spleen enlargement,while the extract from the worm body of CS induced thymus involution without affecting the spleen size.In adrenalectomized mice the thymus atrophic effect oF CS was not observed,while the spleen enlargement still appeared.These results suggest that Cordyceps possesses immuno- pharmacologic activity,and that the active substances exist in the strom of Cordyceps. |
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