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牟德俊,房秀爱.中西医结合治疗再生障碍性贫血41例疗效分析[J].,1985,(12):724-725,707
中西医结合治疗再生障碍性贫血41例疗效分析
An Analysis of the Treatment of 41 Patients with Aplastic Anemia
  
DOI:
中文关键词:  中药治疗  马钱子  再生障碍性贫血  雄性激素  中西药并用  再障  强地松  慢性  重型  七味汤
英文关键词:
基金项目:
Author NameAffiliation
Mou Dejun 中国人民解放军145医院 
Fang Xiuai 中国人民解放军145医院 
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中文摘要:
      41例再障用中药治疗14例,主要用马钱子和七味汤加减;治愈7例,缓解4例.明显进步2例,稳定1例。中西药并用组27例,除用上述中药外加用雄性激素和强地松;其中治愈5例,缓解9例,明显进步4例,稳定4例,两组总有效率87.8%。本文认办马钱子是治疗再障有效而安全的药物。
英文摘要:
      Forty-one patients with aplastic anemia are recognized as 12 cases of acute aplastic anemia and 29 cases of chronic aplastic anemia.Based on Camitta’s standard of serious aplastic anemia,13 cases in the chronic group should be classified as the serious type.The remaining 16 cases in the chronic group are called temporarily the mild type.Treatment and Result:(1)14 patients were treated by the Chinese traditional herbs.They took orally Strychnos pierriana principally and the seven-ingredient decoction composed of Astragalus membranaceus,Rehmannia glutinosa,Polygonum multiflorum,Spatholobus suberectus,Angelica sinensis,Ligusticum chuanxiong and Glycyrrhiza uralensis simultaneously.Doses were strengthened or modified according to diagnosis and treatment.1 patient of the severe type and 6 patients of the mild type were cured,4 improved and 2 patients showed marked progress.(2)27 patients were treated by the above-mentioned drugs.Apart from this prednisone and testosterone were used in the case of the acute group.After the patients of the chronic-severe type were treated by the Chinese traditional herbs for 3 to 6 months with no improvement,10 patients were treated by testosterone and 4 patients by prednisone.When the condition was stabilized 6 patients underwent the excision of their spleens.3 womon of the mild type were treated by a small dose of testosterone.This,in the acute group,3 patients were cured,3 patients showed remission,1 patient had marked improvement and 5 patients died.In the chronic-severe type,2 patients were cured,4 patients showed remission,3 patients had marked improvement and 3 patients stabilized;in the chronic-mild type,2 patients showed remission and 1 patient stabilized.The total effective rate has reached 87.8 percent.The rate of cure and remission has reached 60.25 percent.33 patients have been followed from 1 to 10 years,2 patients have changed their condition, from remission to complete cure,1 case of marked improvement and 1 case of stabilization have changed to remission,but 1 patient has moved back from remission to marked improvement.Others have remained at the same level as when they were discharged from hospital.Therefore it can be concluded that Strychnos pierriana is a safe and effective drug for aplastic anemia.
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