| 查良镒.中药活血化瘀片对于实验性肝损伤的效果研究[J].,1986,(1):36-38,5 |
| 中药活血化瘀片对于实验性肝损伤的效果研究 |
| Treatment of Experimental Liver Injury with Chinese Herbal Medicine Queen Tablet |
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| DOI： |
| 中文关键词: 实验性肝损伤 大白鼠 活血化瘀片 氨基比林 蛋白结合 呼吸试验 肝硬变 保护作用 体重比值 病理检查 |
| 英文关键词: |
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| 中文摘要: |
| 应用活血化瘀片对大白鼠的实验性肝损伤进行了研究,以死亡率、体重变化、肝/体重和脾/体重比值、14C 氨基比林呼吸试验、肝脏蛋白结合羟脯氨酸和病理检查作为对比指标。实验结果显示:活血化瘀片无毒性作用,可使正常大白鼠肝脏蛋白结合羟脯氨酸减少,在减少病死率和减轻肝硬变的形成上,有一定的保护作用。 |
| 英文摘要: |
| The effect of herbal mixture Qucen Tablet（QT）on the liver injury by carbon tetrachloride in the rat was evaluated.Liver injury was induced in female Sprague Dawley rats（initial weight 120～140 g）by a combination of oral phenobarbital（0.5 g/L in the only drinking water provided）and CCI4 inhalation.Animals received CCI4 2～3 times a week for 8 weeks and a closed chamber for periods ranging between 2 and 10 minutes.The animals were divided into 4 groups.Group A:QI only.Group B:CCI4 plus phenobarbital.Group C:CCI4 plus phenobarbital plus QT,Group D:normal control.For a measure of demethylation by the P450enzyme system,the Kel was measured initially and just before sacrificed.Protein bound hydroxyproline was measured in the livers at sacrifice by the method of Rojkind and Gonzale. The deaths of Group A.B.C and D:0/32,9/32,1/32 and 0/11.The liver weight/body weight:2.89%.4.29%, 3.73% and 2.74%.The hepatic protein bound hydroxyproline:3.47±0.7,9.58±1.5,13.0±1.9 and 5.71±0.7（μmol）. The aminopyrine Kel(×10-3)intially:10.93±0.28.10.54±0.54,10.53±0.39 and 11.64±0.27;finally:8.25±0.25, 11.49±0.48,11.11±0.40 and 8.23±0.44,Histology% cirrhotic:0,9/28,1/32 and 0. These data suggest that QT is effective in reducing the liver injury by carbon tctrachloride and phenobarbital. There was a significant reduction in mortality and in the ratio of liver weight to body weight.Histologic cirrhosis was diminished in the Group receiving QT compared to those receiving only carbon tetrachloride and phenobarbital. The effect seems to be independent of the P450enzyme system as QT did not appear to effect demethylation by this enzyme system in the presence of carbon tetrachloride and phenobarbital. |
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