| 鲍军,洪允祥,楼建国,张华,李灵,俞秋棠,朱善济.家兔急性血瘀模型的研究[J].,1986,(6):357-359,326 |
| 家兔急性血瘀模型的研究 |
| Experimental Study on Acute Blood Stasis Model in Rabbits |
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| DOI： |
| 中文关键词: 急性血瘀模型 注药 实验兔 高分子 纤维蛋白原 血小板形态 血栓形成 葡聚糖 家兔 血小板数 |
| 英文关键词: |
| 基金项目: |
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| 中文摘要: |
| 本文用改良高分子葡聚糖法研制家兔急性血瘀模型,实验与对照兔在外形、内脏外观及病理切片、血凝、纤溶、血小板数等均有显著差异(P<0.05～0.001),符合全国血瘀证诊断标准,重复性好,动物无一死亡。本模型为血瘀理论及临床提供了重要的研究手段。 |
| 英文摘要: |
| Based on the close relationship between hypercoagulation and blood stasis,the author devised the acute blood stasis model of rabbit by injecting dextran of high molecuiar weight mixed with thrombin into the vein of rabbit’s ear.ATIII,KPTT,PT,Fbg,FDP were tested constantly as observing criteria.The change of these indices caused by injection is statistically significant(P<0.05～0.001). The rabbit became inactive after injection and cyanosis appear in the rabbit’s ears,blood stasis and hemorrhage could be seen in the lungs,liver,kidneys and other internal organs of rabbits.Thrombosis and congestion could be observed under the light microscopy.The platelet counts decreased and the majority of platelets broke into fragments,the pseudopodia formation and dense aggregation occurred in a minor part of platelets under the scanning electron microscopy.PO.and SO.lowered as well. All the changes described above appeared immediately after injection and persisted for 6～12 hours and is correspgnding with the diagnostic criteria of blood stasis set by the Specialized Committee of Promoting the Blood Circulation and Relieving the Stasis.So it could be taken as an acute blood stasis model. This model is recommendable for the following advantages:The material is easy to get.the method is simple,and the experimental animal does not die from injection. |
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