| 金亚城,胡关海,朱正中,戴培兴,康凤春,詹学斌,冯尚炽,方宗桥,陈志成,戚国堡,邹烈钧,章少敏,徐桂兰,李习鹏,吴行之.番泻叶对急性胃、十二指肠出血的临床观察和实验研究[J].,1986,(8):455-457,451 |
| 番泻叶对急性胃、十二指肠出血的临床观察和实验研究 |
| Clinical Effect and Experimental Study on Folium Sennae in Acute Gastroduodenal Hemorrhage |
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| DOI： |
| 中文关键词: 番泻叶 十二指肠 止血时间 止血作用 实验研究 止血效果 上消化道出血 急性 草酸钙簇晶 口服 |
| 英文关键词: |
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| 中文摘要: |
| 番泻叶粉口服治疗急性胃,十二指肠出血340例获良效,平均止血时间2.68天,优于常规止血西药、甲氰咪胍及大黄的疗效,差别显著。从番泻叶中提取总蒽醌甙,得率为4%,经分离为番泻叶甙 A、B、C、D,动物实验证实其有明显止血作用;番泻叶中含有晶纤维与草酸钙簇晶具有局部止血作用。 |
| 英文摘要: |
| Effects of the Folium Sennae on acute gastroduodenal hemorrhage in 340 cases were observed.The results showed that the Folium Sennae administered orally was effective in hemostasis.The total effective rate reached 94%,average hemostatic time 2.68 days,which was more effective than control groups (conventional medicine,Cimetidine and Rheum officinale group). The-Folium Sennae glycoside was isolated from its leaves,extraction rate 4%,and its marked hemostatic effect was fully demonstrated by animal experiment.According to the determination of bleeding and coagulation parameters,after this drug was given orally,the result suggests that the Folium Sennae glycoside can increase platelet and fibrinogen quantitatively,coagulation time,thromboplastin time and clot retraction time were shortened,which will benefit the hemostatic effect.The Folium Sennae glycoside promotes not only intracoagulative and antifibrinolytic effect in acute gastroduodenal hemorrhage but also local hemostatic function.It can play a role in stopping the bleeding by removing the intra-intestinal blood stasis through promoting the colon peristalsis.This drug does not irritate stomach,duodenum and small intestine and do no harm to the lesion of bleeding.The above results suggest that this satisfactory hemostatie effect may be due to the removing of blood stasis. |
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