| 王大元,程美璋,万春根,张淑娥,陈庭芬,戴培兴.夏天无生物碱对麻醉犬脑循环与下肢循环的作用[J].,1986,(8):477-479,454 |
| 夏天无生物碱对麻醉犬脑循环与下肢循环的作用 |
| Effects of Alkaloids of Corydalis Decumbers on Cerebral and Peripheral Circulation in Dogs |
| |
| DOI： |
| 中文关键词: 夏天无总碱 普托品 下肢血管 去甲肾上腺素 脑血管功能 夏天无总生物碱 麻醉犬 脑循环 脑血管阻力 静脉注射 |
| 英文关键词: |
| 基金项目: |
|
| Hits: 1473 |
| Download times: 1083 |
| 中文摘要: |
| 本文报告夏天无生物碱可使麻醉犬脑与下肢血流量增加,血管阻力减低(经统计学处理均有显著性差异)、血压轻度下降。提示其有扩张脑血管和下肢血管的作用。并可对抗去甲肾上腺素引起的脑血管与下肢血管的紧张状态。该药不能解除5-羟色胺所产生的脑血管紧张状态。其扩张脑血管作用不被阿托品阻断。 |
| 英文摘要: |
| Effects of the total alkaloids of Corydalis decumbers(TACD)and its principal alkaloid,protopine,on cerebral and peripheral circulation were studied in 75 anesthetized dogs. TACD 1 mg/kg given intra-arterially induced a significant increase of cerebral b1ood flow,a striking reduction of its vascular resistance and a falling of the systemic blood pressure.When the cerebral vessels were in a hypertonic state induced by noradrenaline,intra-arterial injection of TACD could still show the same reactions,but could not affect the vasoconstricting response of serotonin on the cerebral vessels. TACD 5mg/kg given intravenously showed no significant influence on cerebral blood flow and its vascular resistance.For peripheral blood flow,1 mg/kg of TACD administered intra-arterially induced a significant increase of femoral blood flow and a marked decrease of its vascular resistance;but such effects were not recorded in i.v.given TACD 5 mg/kg. Protopine 0.2 mg/kg given intra-arterially produced similar effects both on cerebral and femoral circulation as TACD 1 mg/kg given intra-arterially.Intravenous injection of protopine 2 mg/kg caused an increase of both cerebral and femoral blood flow,a reduction of their vascular resistance and a falling of the systemic blood pressure.These results indicate that TACD and protopine possess the effect of vasodilation on cerebral and peripheral vessels. |
| View Full Text View/Add Comment Download reader |
|
|
|
