欢迎访问中国中西医结合杂志！

旧版登录

Chinese Version

Online office

Journal Online

Forthcoming Articles >>

Current Issue >>

Next Issue >>

Earlier Issues >>

Download

Top

Top Downloaded
Top Cited

Links

朱希伟,隋文作,印晓光,郝宏党.小蘖胺抗肿瘤作用的实验研究[J].,1986,(10):611-613,582

小蘖胺抗肿瘤作用的实验研究

Experimental Study on Anti-Tumor Action of Berbamine in Mice

DOI：

中文关键词: 小蘖胺抗肿瘤作用小鼠移植性肿瘤生命延长率实验研究肿瘤细胞实验组抑制作用超微结构观察汉防己甲素

英文关键词:

基金项目:

Author Name	Affiliation
Zhu Xiwei	辽宁中医学院
Sui Wenzuo	辽宁中医学院
印晓光	辽宁中医学院
郝宏党	辽宁中医学院

Hits: 1339

Download times: 1072

中文摘要:

本文通过动物抗肿瘤实验,证明小蘖胺对小鼠 S₁₈₀的抑制率为75～78%;对小鼠HAC 的生命延长率为68～80%;对小鼠 EAC 的生命延长率为68～80%。病理学及超微结构观察,提示实验组肿瘤细胞有坏死现象和代谢受阻情况。小蘖胺的急性 LD₅₀为112±0.04mg/kg。

英文摘要:

This paper reports on the effect of berbamine treatment of tumor in mice.After hypodermic transplantation of 4.0×10⁵ S₁₈₀cells and intraperitoneal transplantation of 4.0×10⁵ HAC or EAC ascitic tumor cells,the mice in the berbamine treated group was given 20 mg/kg berbamine intraperitoneally,once daily for ten days.The growth suppressing rate of S₁₈₀tumor cells was 75～78%,and the lifespan extension rate of the mice with HAC and EAC was 68～80% in the berbamine treated group.Light and electron microscopic examination showed that there were necrosis and metabolic disturbance in the tumor cells treated by berhamine.The experimental result showed that berbamine can suppress the transplanted tumor in mice effectively.

View Full Text View/Add Comment Download reader