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姚泰,肖永福,孙祥莺,童华华,袁曼,徐肇明,戴自英.山莨菪碱对内毒素休克狗心血管活动的效应[J].,1986,(11):679-681,646

山莨菪碱对内毒素休克狗心血管活动的效应

Cardiovascular Effects of Anisodamine During Endotoxin Shock in Anaesthetized Dogs

DOI：

中文关键词: 内毒素休克大肠杆菌内毒素左心室内压平均动脉压山莨菪碱心肌收缩能力左心室收缩压感染性休克动物肾血流量

英文关键词:

基金项目:

Author Name	Affiliation
Yao Tai	上海医科大学基础医学部生理学教研室
Xiao Yongfu	上海医科大学基础医学部生理学教研室
孙祥莺	上海医科大学基础医学部生理学教研室
童华华	华山医院传染病学教研室
袁曼	华山医院传染病学教研室
徐肇明	华山医院传染病学教研室
戴自英	华山医院传染病学教研室

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中文摘要:

给麻醉狗静脉注射大肠杆菌 O₁₁₁B₄内毒素5mg/kg 引起休克,60分钟后经股静脉注入山莨菪碱5mg/kg 后,可使心率加快,平均动脉压回升,左心室心肌收缩能力改善,肾血流阻力降低,肾血流量和尿量都增加。在对照组动物中仅给等容积的生理盐水,未出现上述变化。

英文摘要:

Experiments were carried out on-mongrel dogs anaesthetized with pentobarbital.Escherichia coli endotoxin(5 mg/kg)was given intravenously to produce circulatory shock.In 6 dogs,anisodamine(5 mg/kg)infused intravenously over a period of 60 min.caused increase in heart rate,left ventricular systolic pressure,positive and negative maximum dp/dt and mean arterial pressure.Renal blood flow and urinary outflow also raised.No such changes were observed in the control group of 6 animals which received saline infusion only.The results obtained indicate that anisodamine given at early stage of endotoxin shock improves myocardial contractility.

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