| 王硕仁,乐兆升,吕小燕,姚素珍,邓玉平,刘娴芳,廖家桢,郭维琴,曹继平,任映,杨金铎,王兆海,赵忠印,霍艳明,汪钟,黄如松,安岩,朱国强.气血注射液对冠心病患者血小板功能的影响[J].,1987,(1):12-14,3 |
| 气血注射液对冠心病患者血小板功能的影响 |
| Effects of Qixue Injection on Function of Platelet in Coronary Heart Disease Patients |
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| DOI： |
| 中文关键词: 血小板聚集 注射液 冠心病患者 血小板功能 抑制作用 血小板粘附功能 中医辨证 气血 气虚血瘀 血液 |
| 英文关键词: |
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| 中文摘要: |
| 本文观察了不同剂量的气血注射液（含人参、黄芪、当归）对29例冠心病患者血小板粘附、聚集功能及血浆 TXB2（血栓素 B2）、6-keto-PGF1α(6-酮-前列腺素 F1α)含量的作用。结果说明气血注射液体内试验对血小板粘附功能有明显的抑制作用;对中医辨证属气虚血瘀的冠心病患者的血小板聚集有明显的抑制作用,而对辨证属阴虚血瘀或挟有痰湿者则有可能促进其血小板聚集的作用。初步说明了该药物的证效关系。气血注射液尚有使血浆 TXB2含量明显下降、血浆6-keto-PGF1α含量明显增加的作用。 |
| 英文摘要: |
| The purpose of the present study was to evaluate the effects of Qixue injection（QXI）on platelet adhesion,platelet aggregation,plasma TXB2 level and 6-keto-PGF1αlevel in 29 coronary heart disease （CHD）patients who has received QXI at various doses（20 ml or 40 ml）.QXI was prepared by Dongzhimen Hospital consisting of Panax ginseng,Astragalus membranaceus and Angelica sinensis,and was administered intravenously.The tesults showed that 1 hr after a single dose of 20 or 40 ml QXI i.v.,the rate of platelet adhesion was reduced from 27.07±2.27%（pre-QXI）to 14.46±5.83%（post-QXI,P<0.05）.In case of CHD with Qi deficiency and stasis of blood,the rate of platelet aggregation was lowered significantly with QXI, the inhibitory rate of platelet aggregation was 56.93%（P<0.05）.But in control,thc CHD patients with Yin deficiency or"phlegm-dampness",the platelet aggregation was increased slightly（P>0.05）.It showed that the relationship between the syndrome of TCM and effectiveness do existed.The plasma TXB2 level was reduced significantly from 260.28±164.4 to 139.28±57.01 pg/ml（P<0.05）.While the plasma 6-keto-PGF1α level was increased from 33.45±22.5 to 57.48±13.1 pg/ml（P<0.01）.In order to further study the effect of QXI on PGI2,16 rats were divided into 4 groups:（1）Tween-80 control group（0.4% Tween-80 0.5 ml/100 g i.p.）,（2）QXI A group（QXI 0.25 ml/100 g i.p.）,（3）QXI B group（QXI 0.5 ml/100 g i.p.）,（4）indomethacin group（indomethacin 1.25 mg/100 g p.o.）.The plasma 6-keto-PGF1αlevels in 4 groups were 185.77±66.48 pg/ml,182.59±36.02 pg/ml,366.33±165.87 pg/ml and 37.29±3.24 pg/ml respectively.It is known that blood platelet play an important role in the pathogenesis of CHD.The results of the present study suggested that QXI had a beneficial effect on blood platelets in CHD.According to the theory of TCM,the pathogenesis of CHD is Qi deficiency and blood stasis.QXI had the action of replenishing the Qi and promoting the blood circulation,hence a beneficial efficacy was obtained. |
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