| 彭伟,段生福.川芎嗪治疗失代偿期慢性肺心病的临床研究[J].,1987,(1):26-29,5 |
| 川芎嗪治疗失代偿期慢性肺心病的临床研究 |
| Clinical Study of Ligustrazini in Treating Chronic Cor Pulmonale |
| |
| DOI： |
| 中文关键词: 川芎嗪 慢性肺心病 失代偿期 血液流变学变化 心输出量 动脉血气 右心功能 肺血管阻力 血液流变性 治疗前后 |
| 英文关键词: |
| 基金项目: |
|
| Hits: 1388 |
| Download times: 927 |
| 中文摘要: |
| 本文采取自身对照方法,对49例失代偿期慢性肺心病患者观察了用川芎嗪(120mg)静脉滴注治疗一个疗程后的临床疗效。结果表明:川芎嗪能扩张肺血管、降低肺动脉的平均压(AP)和肺血管阻力(PVR)、增加心输出量、改善右心功能和血液流变性,使临床症状减轻,对动脉血气无明显影响,适于失代偿期肺心病的治疗。 |
| 英文摘要: |
| Self-contrasted method was used in observing 49 patients with advanced cor pulmonale.They were divided into two groups,A and B groups（A group:control period followed by course of treatment;B group:vice versa）.Before and after intravenous administration of ligustrazini（120 mg）,pulmonary hemodynamic,right cardiac function,hemorheology and arterial blood gas were determined in these patients.After one course of treatment,A and B group showed that:Pap decreased by 6.84 and 6.73 mmHg respectively.PVR lowered for 87.08 and 71.34 dyn·s·cm5,CO elevated for 1.05 and 1.23 L/min.,HR reduced for 7.9 and 6.8 beats/min.,Q-B interval shortened for 0.03 and 0.03 sec.,B-Y interval prolonged for 0.03 and 0.05 sec.,Q-B/B-Y ratio,Q-BI and B-YI improved,HS elevated by 0.05 and 0.06 Ω,α time prolonged by 0.02 and 0.03 sec.;the whole blood viscosity（high）decreased for 1.36 and 1.20,whole blood viscosity（low）reduced for 4.27 and 4.19;plasma viscosity lowered for 0.66 and 0.43,RBC electrophoretic time shortened by 6.74 and 6.34 sec.,hematocrit decreased for 6.92 and 3.75% respectively.These changes of parameters were significant in the course of treatment with ligustrazini（P<0.05～0.01）,but not significant in the control period of treatment.Arterial blood gas changes were observed in 6 patients.After treatment with ligustrazini,results showed that the PaCO2 was significantly reduced from 65.2±10.0 to 61.3±8.5 mmHg （P<0.05）.Except that,the pH,PaO2 and SaO2 did not significantly change.These results showed the ligustrazini was effective in"promoting the blood circulation and removing the blood stasis",namely,in dilating the pulmonary vessels,decreasing Pap and PVR,and improving right cardiac function as well as hemorheological quality in treating patients with cor pulmonale. |
| View Full Text View/Add Comment Download reader |
|
|
|
