| 钱伯初,陈珏,臧星星,许衡钧,汤蕾,范华芬.哮喘宁免疫药理研究——抗Ⅲ、Ⅳ型变态反应[J].,1987,(1):38-41,6 |
| 哮喘宁免疫药理研究——抗Ⅲ、Ⅳ型变态反应 |
| Effects of Xiao Chuan Ning on Types Ⅲ and Ⅳ of Allergic Reaction |
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| DOI： |
| 中文关键词: 哮喘宁 变态反应 药理研究 抑制作用 免疫复合物 溶血素抗体 接触性皮炎 小鼠脾脏 家兔血清 体液免疫反应 |
| 英文关键词: |
| 基金项目: |
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| 中文摘要: |
| 由黄芩,丹皮、桂枝、甘草的乙醇及水提取物组成的哮喘宁,对Ⅲ型变态反应模型家兔主动 Arthus 反应和大鼠被动 Arthus 反应有明显抑制作用,并能降低用卵白蛋白和弗氏完全佐剂多次免疫家兔的血清免疫复合物含量;对Ⅳ型变态反应模型小鼠 DNCB 接触性皮炎和小鼠 SRBC 足垫反应亦有显著抑制作用;对小鼠脾脏溶血空斑数和血清溶血素抗体未见影响。这些结果为哮喘宁的临床应用提供了实验依据。 |
| 英文摘要: |
| Xiao Chuan Ning(XCN)is composed of alcoholic and aqueous extracts of medicinal herbs,Scutellaria baicalensis,Paeonia suffruticosa,Cinnamomum cassia and Glycyrrhi=a uralensis.The present study was undertaken to observe the effects of XCN on types Ⅲ and Ⅳ of allergic reactions and humoral immunity. XCN was given intraperitoneaily in a dose of 2 g/kg per day for 7 or 10 consecutive days prior to the challenge with antigen in rabbits and rats.As compared with the control,it was shown that an inhibitory effect on active Arthus reaction in pretreated rabbits 2 to 6 hrs after the challenge and passive Arthus reaction in pretreated rats 1 to 3 hrs after the challenge.The increase of serum immune complex in rabbits induced by repeated injections of egg albumin and complete Freund’s adjuvant was inhibited significantly by given XCN either orally 20 g/kg per day for 6 days or intraperitoneally 2 g/kg per day for 3 days. XCN(20 and 40/kg per day,orally for 20 days)inhibited contact dermatitis on ears of mice caused by 2,4-dinitrochlorobenzene(DNCB),their inhibition rate were 60.8% and 67.27% respectively.The same doses were given orally for 15 consecutive days in mice,their delayed footpad reaction induced by sheep red blood cells(SRBC)were inhibited,the inhibition rate were 51.8% and 45.7% respectively.As comparing with control,the differences were significant statistically(P<0.05～0.001 ) On the humoral immune response to SRBC in mice.XCN affected neither the number of plaque forming cells of spleen nor the level of serum hemolysin. From these results,XCN displays the inhibition of types Ⅲ and Ⅳ of allergic reactions and no effect on the humoral immune response.These actions of XCN may be helpful for use in the treatment of asthma. |
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