| 赵伟康,潘迎宪,万叔援,徐凤仙,郭振英,严凌鹤.还精煎对老年小鼠胸腺超微结构及性激素受体的作用观察[J].,1987,(4):226-228,198 |
| 还精煎对老年小鼠胸腺超微结构及性激素受体的作用观察 |
| Effect of "Essence-Restoring Decoction" on Thymic Ultrastructure and Sex Hormone（E2 and DHT）Receptors in Senile Mice |
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| 中文关键词: 还精煎 超微结构 小鼠胸腺 胸腺重 性激素受体 老年性 老年小鼠 核受体 延缓衰老 上皮性网状细胞 |
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| 中文摘要: |
| 本文观察了以填补肾精为主的延缓衰老方剂还精煎对老年小鼠胸腺超微结构及胸腺性激素受体等的影响。结果表明还精煎能明显提高老年小鼠胸腺重量;改善胸腺超微结构的老年性变化;使胸腺胞浆蛋白质、核 RNA 和 DNA 含量显著增加;并减少胸腺核雌二醇（E2）受体和双氢辜酮（DHT）受体数量,从而减弱 E2、DHT 对胸腺的致萎缩作用。还精煎的上述作用提示填补肾精法延缓衰老可能与调整下丘脑—垂体—性腺—胸腺轴功能有关。 |
| 英文摘要: |
| The clinical effect of"Essence-Restoring Decoction",a kidney essence tonifying recipe on retarding aging,has been reported.This paper presents the pharmacological effects of Essence-Restoring Decoction on thymic ultrastructure and thymic sex hormone（E2 and DHT）receptors in C557 BL/6J senile mice.The results showed that"Essence-Restoring Decoction"was able to increase the thymic weight,or the thymic weight （mg）per body weight（g）（P<0.001）,and markedly enhance the concentration of thymic cytosol protein as well as nuclear RNA and DNA of the senile mice（P<0.001）.The senile change of ultrastructure of thymus was studied under electronmicroscope,the thymus of senile mice had an obvious atrophy.In cytoplasm of thymic lymphocytes,there were swelling degeneration of mitochondria,disappearance of its cristae,and reduction of the ribosome,while in epithelial reticular cell,besides the above change in mitochondria,the nuclear chromatin was concentrated.However,the senile change of the thymus of"Essence-Restoring Decoction"-treated aged mice was retarded.The ultrastructure of its thymus became nearly normal.The amount of thymic cytosol and nuclear E2 and DHT receptors were estimated respectively.It was found that the Essence-Restoring Decoction was able to reduce the amount of thymic nuclear E2 receptor（P<0.01）and DHT receptor（P<0.05）,thus the effect of the inhibition and atrophy of E2 and DHT to thymus was reduced.The mechanism of the decrease of nuclear E2 and DHT receptors may be due to the obstruction on the translocation of the sex hormone receptors from cytosol to nucleus or the change of the permeability of nuclear membrane.It was suggested that the retardation of aging by the method of tonifying kidney essence may be related to the regulating of hypothalamus-pituitary-gonadal thymic axis. |
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