| 许兆祥,李蕾琴,曲凤珍,王燕平.丝瓜藤提取物对机体和体外细胞的抗病毒感染效果[J].,1987,(7):421-422,390 |
| 丝瓜藤提取物对机体和体外细胞的抗病毒感染效果 |
| Antiviral Efficacy of the Extract of Luffa cylindrica Vine in Vivo and in Vitro |
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| DOI： |
| 中文关键词: 丝瓜藤 提取物 干扰素诱生剂 慢性支气管炎 呼吸道病毒感染 乙脑病毒 小白鼠 组织培养细胞 感染活性 保护率 |
| 英文关键词: |
| 基金项目:本课题受中国科学院科学基金资助 |
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| 中文摘要: |
| 本实验证明,丝瓜藤提取物(ELcv)对小白鼠感染乙脑病毒以及对组织培养细胞感染滤泡性口腔炎病毒(VSV),有很明显的预防作用;并证明 ELcv 是核酸类的干扰素诱生剂。作者认为,由于干扰素诱生剂是一种广谱的抗病毒物质。民间用新鲜丝瓜藤的汁治疗慢性支气管炎,可能与它能预防呼吸道病毒感染有关。 |
| 英文摘要: |
| The antiviral activity of the extract of Luffa cylindrica vine(ELCV)on virus infection in vivo and in vitro was studied,Results from the study indicated that:(1)The mice resulted in a 66.7～80% protection when the ELCV was given to mice prior to infection with Japanese encephalitis virus,but only a weak protection of the treated mice could be observed when given after infection;(2)The ELCV was highly active in inducing resistance to cytopathic changes in primary rabbit kidney cell cultures challenged with vesicular stomatitis virus; (3)Interferon was induced in rabbit by intravenous injection with the ELCV.The circulating serum interferon level peaked at 2 hr after injection;(4)The antiviral activity of the ELCV was greatly lowered by heating at 100℃ for 45 min.and was partially resistant to RNase at concentration of 20 μg/ml;(5)Ultraviolet spectrum of the ELCV revealed a pattern of nucleic acids. |
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