| 赵波,黄献诚,杜宏微,吴小春,王贵喜,李树浓.雷公藤延长同种小鼠心肌移植物存活时间的研究[J].,1988,(1):31-33,6 |
| 雷公藤延长同种小鼠心肌移植物存活时间的研究 |
| Study of Tripterygium wilfordii on Prolonging Survival Time of Mice Myocardial Allografts |
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| 中文关键词: 雷公藤片 存活时间 肌移植物 小鼠 生理盐水 心肌移植 移植模型 排斥反应 生药 移植物存活 |
| 英文关键词: |
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| 中文摘要: |
| 本文采用小鼠心肌移植模型观察了雷公藤对排斥反应的影响。结果表明,雷公藤生药及雷公藤片可明显延长小鼠心肌移植物的存活时间,明显降低心肌移植物的排斥率。组织学检查表明,移植术后12天,给药组移植心肌结构基本完整,而生理盐水对照组的心肌广泛坏死,内有大量淋巴细胞浸润。 |
| 英文摘要: |
| Myocardial tissues of new-born BALG/c mice(within 24 hrs after birth)were transplanted to adult NIH mice as free allografts.ECG activity was used to detect rejection.Three groups of mice were treated with Tripterygium wilfordii Hook f.in doses of 0.05g/day,0.10 g/day and extract- tablets Tripterygium wilfordii 0.10g/day,p.o..The control groups were treated with normal saline (NS)and azathioprine.The average survival time of grafted heart tissue for the NS group was 12.3± 2.9 days and for the azathioprine group 17.8±2.9 days.The survival time of grafted heart tissue was significantly prolonged by Tripterygium wilfordii and its extracts.The average survival time was as follows:for 0.05 g/day 18.5±2.7 days,for 0.10 g/day 19.3±2.7 days and for extract-tablets 20.7±1.2 days.Comparing the above-mentioned groups with the NS group,the difference was significant,P< 0.001.The survival time for extract-tablets group was longer than that of the azathioprine group(P< 0.05).Comparing the rejection percentage at definite times,the rate of drug administrated groups decreased remarkably:Ten days after transplantation,57% of the NS group were rejected,and none of the drug administered groups were rejected(P<0.05).19 days after transplantation,100% of the NS-group were rejected,but the extract group for 0.10 a/day only 17% were rejected(P<0.05).A histological examination of the grafts revealed that there were large amount of lymphocytes and certain amount of monocytes infiltrated in the broken-down myocardial fibers in the control groups 12 days after transplantation.While in the drug administered groups,the myocardial fibers remained intact.All these data mentioned suggested that Tripterygium wilfordii can prolong the survival time of allografted myocardial tissue significantly.Its mechanism is possibly the inhibition of cell- mediated and humoral immunity. |
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