| 王更新,贲长恩,叶百宽,杨美娟,高俊玲.联苯双酯对大鼠实验性肝损伤修复作用的组织化学和电镜观察[J].,1988,(3):158-160,133,134 |
| 联苯双酯对大鼠实验性肝损伤修复作用的组织化学和电镜观察 |
| Study on Repairing Effects of Biphenyl Dimethyl Dicarboxylate On Experimental Liver Injury in Rats with Histochemical and Electron-Microscopic Observation |
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| 中文关键词: 组织化学 电镜细胞化学 电镜观察 肝细胞 修复作用 实验性肝损伤 联苯双酯 周边区 中央区 治疗后 |
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| 中文摘要: |
| 本实验用组织化学、电镜和电镜细胞化学等方法观察联苯双酯对四氯化碳所致肝损伤后的治疗作用。结果表明:联苯双酯对四氯化碳所致大鼠肝损伤具有明显的修复作用,促使细胞中的内质网、线粒体、溶酶体、某些酶、糖原和脂滴等均恢复近正常水平。 |
| 英文摘要: |
| Biphenyl dimethyt dicarboxylate（BDD）is a new drug having a beneficial effect in treatment of viral hepatitis.In this paper,the effect of BDD on morphological study of experimental liver injury in rats was made.48 adult male rats were selected for the experiment.The animals were divided into 3 groups（control,liver injury and treated group）.The liver injury was induced by means of subcutaneous injection of CCl4.Eight days after first injection,the animals were decapitated,their livers were studied by means of histochemistry and electron-microscopic cytochemistry.The result showed that in BDD treated group the liver cell adiposis was milder,the activity of CCO,N-Ease, G-6-pase and so on recovered markedly,the membrane system（ER,Mit,etc.）recovered to approxi- mately normal condition.It suggested that BDD has an obvious repairing action on CCl4 induced liver injury in rats. |
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