| 赵智强,曹一鸣,许长照,王九林,陆耀鸣,俞晶华,朱宏,王耿.凉血化瘀方对家兔DIC高凝期的作用观察[J].,1988,(4):218-220,197 |
| 凉血化瘀方对家兔DIC高凝期的作用观察 |
| Observation on Effect of Liangxue-Huayu Prescription on High Coagulation Phase of DIC in Rabbits |
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| DOI： |
| 中文关键词: 凉血药 家兔 大肠杆菌内毒素 凉血化瘀方 球结膜微循环 病理变化 纤维蛋白原含量 红细胞压积 病理形态学 血浆复钙时间 |
| 英文关键词: |
| 基金项目: |
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| 中文摘要: |
| 本实验在建立 DIC 高凝期模型的基础上,选用凝血、纤溶、血液流变、球结膜微循环、病理形态学及动物病死率等指标,探讨中医凉血化瘀药作用原理。实验结果表明:凉血药与活血化瘀药配伍,对大肠杆菌内毒素诱导家兔 DIC 高凝期有预防作用,对高凝期上述各指标均表现有不同程度的改善,提示其主要作用环节在于改善高凝期这一时相的病理变化。 |
| 英文摘要: |
| The model of high coagulation phase of DIC in rabbit was established in our laboratory.It was used to study the relationship between"blood heat with stasis"syndrome and high coagulation phase of DIC,and the mechanism of liangxue-huayu(LXHY,cooling blood and relieving stasis)therapy. The results indicated that the"heat flaming in blood portion"syndrome and the"stagnation of blood channel"syndrome in TCM were closely related with the pathologic changes in DIC caused by the infection.The preventive effect of LXHY prescription for high coagulation phase of DIC caused by E.Coli endotoxin in rabbits was proved.The results of examining blood coagulation,hemorrheology and conjunctiva microcirculation showed that the pathologic changes of the therapeutic group could be alleviated,which suggested that the protective effect of LXHY therapy was related to the action of improving coagulation,microeirculation and blood viscosity of affected rabbits.Thus the path- ologic process might be abated and blocked,the blood flow in some viscera increased and the shock would be prevented. |
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