| 高树伟,陈在嘉,陶寿淇,徐理纳.阿魏酸钠对冠心病患者血小板聚集及血小板TXA2的影响[J].,1988,(5):263-265,259 |
| 阿魏酸钠对冠心病患者血小板聚集及血小板TXA2的影响 |
| Effects of Sodium Ferulate on Platelet Aggregation and Platelet TXA2 in Patients with Coronary Heart Disease |
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| 中文关键词: 阿魏酸钠 抑制血小板聚集 冠心病患者 血小板功能 血小板聚集性 显著影响 不同浓度 观察 依赖型 葡萄糖盐水 |
| 英文关键词: |
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| 中文摘要: |
| 本文报道观察阿魏酸钠对冠心病患者血小板功能影响的结果,表明阿魏酸钠在体外可显著抑制血小板聚集及血小板 TXA2生成,其作用呈浓度依赖型。阿魏酸钠4mg/kg 静脉滴注未观察到对冠心病患者血小板功能有显著影响,可能与剂量不足有关。 |
| 英文摘要: |
| Sodium ferulate（SF）,one of the active principles of Angelica sinensis,was investigated in vitro and in vivo for its anti-platelet effects.In vitro,SF inhibited platelet aggregation was induced by epinephrine or ADP as well as inhibited platelet TXB2（a metabolite of TXA2）generation,which occurred in the platelet rich plasma of patients with CHD,in a dose dependent fashion.At low concentration,SF showed a markedly inhibitory effect on platelet TXB2 generation more than that on platelet aggregation.While at a higher concentration,platelet aggregation was more evidently suppressed than platelet TXB2 generation.The results suggest that SF,in vitro,could effectively inhibit the platelet aggregation in patients with CHD,which was partly related to the inhibition of TXA2 generation.SF was also intravenously infused,in a dosage of 4 mg/kg.However,both 6-keto-PGF1aand TXB2 in plasma and in serum remained unchanged;platelet aggregation and platelet TXB2 generation were lower than the values measured before SF infusion,but,as compared with placebo,no significant difference statistically was observed.Inadequate dosage might be the main cause for the failure. |
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