| 郭肇铮,卢(讠永)才,刘小青,王淑华,周玉琳,贾绪东,汪建,甄二真.白首乌抗自由基损伤的研究[J].,1988,(5):282-284,262 |
| 白首乌抗自由基损伤的研究 |
| Prevention against Free Radical Damage in Mice with Cynanchum auriculatum |
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| DOI： |
| 中文关键词: 白首乌 超氧化物歧化酶 模型组 抗自由基损伤 过氧化脂 小鼠 单胺氧化酶 何首乌 酶活性 体重减轻 |
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| 中文摘要: |
| 本文报告小鼠吸臭氧（O3）后形成自由基损伤动物模型及中药白首乌抗损伤的功效。结果:模型组出现体重减轻、体温降低、体力减弱、御寒能力下降等一系列生理功能减退的变化,并测得脏器过氧化脂含量增加、脑单胺氧化酶-B 活性提高等生化改变。这些变化与老龄小鼠的变化相似。服首乌的小鼠以上这些指标都得到改善,血超氧化物歧化酶活性下降,接近正常组水平。证明白首乌有抗自由基损伤功能,是一种预防与治疗 O3损伤的有效药物,也可能是一种有前途的延缓自然衰老的药物。 |
| 英文摘要: |
| Mice(NIH)of 27±3g were divided into:Ⅰ.control group,Ⅱ.model group and Ⅲ.Cynanchum auriculatum Royle ex Wight(CARW)group.Group Ⅱ was modelled by caging mice in an ozone room of 0.9 ppm concentration for 10 days.A dose of 60 mg CARW/day was given to the mice group Ⅲ for 20 consecutive days,10 days prior to and 10 days during the ozone inhalation together with the model mice.The results showed that the ozone inhalation was injurious to mice resulted in signifi- cant increase of SOD activity of red blood cell,LPO content in lung,liver and brain tissue,and MAO content in brain,while in CARW group,the value of corresponding indices mentioned above was lowered and normalized.Physically the CARW mice got restoration of strength and health from debilitated condition caused by ozone damage and were much more tolerant to cold than model mice. These results indicated that CARW displayed an inhibitory effect on ozone induced free radical damage.The action of CARW may be helpful for use as an effective medicine for delaying aging process. |
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