| 许得盛,沈自尹,胡国让,陈伟华,涂灏,黄淑玲.温阳片对哮喘患者组胺释放、IgE作用的同步观察[J].,1988,(6):330-332,323 |
| 温阳片对哮喘患者组胺释放、IgE作用的同步观察 |
| Observation on Effect of Wenyang Tablet on Histamine Release,Serum IgE in AsthmatiCs |
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| DOI： |
| 中文关键词: 组胺释放 特异性 哮喘患者 季节性 温阳 哮喘发作 支气管哮喘 挑刺 血清 尘螨 |
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| 中文摘要: |
| 本文报告以组胺释放率、血清总 IgE、尘螨特异性 IgE 及皮肤挑刺试验等为指标,进一步探究温阳片预防支气管哮喘发作的机理。在温阳片获效的同时,哮喘患者血清总 IgE 和尘螨特异性 IgE 的季节性升高受到明显抑制,组胺释放率明显下降;尘螨皮肤挑刺试验也呈好转趋势,表明温阳片可能通过抑制总 IgE 和特异性 IgE 的季节性升高,从而减少组胺等过敏介质的释放,以至减轻或中止哮喘的季节性发作。本文报告以组胺释放率、血清总 IgE、尘螨特异性 IgE 及皮肤挑刺试验等为指标,进一步探究温阳片预防支气管哮喘发作的机理。在温阳片获效的同时,哮喘患者血清总 IgE 和尘螨特异性 IgE 的季节性升高受到明显抑制,组胺释放率明显下降;尘螨皮肤挑刺试验也呈好转趋势,表明温阳片可能通过抑制总 IgE 和特异性 IgE 的季节性升高,从而减少组胺等过敏介质的释放,以至减轻或中止哮喘的季节性发作。 |
| 英文摘要: |
| Wenyang Tablet(WYT)was given to 77 adult asthmatics and placebo tothe other 25 asthmatics as control.The results showed that the total effective rate was 89.6% and the markedly effective rate was 53.2% in WYT group,significantly higher than 20%0 and 4% of the controls(P<0.005). There was no significant difference in serum IgE and specific IgE levels,histamine release and skin prick test between WYT group and controls before treatment(in July).After treatment(in October), however,serum IgE and specific IgE levels were increased in the controls(P<0.005)and decreased in WYT group(P<0.005),showing that the seasonal increase of serum IgE and specific IgE could be inhibited by WYT.Meanwhile,histamine release rate was decreased from 15.7% before treatment to 8.4% after treatment in WYT group(P<0.001),whereas the controls was 14.9.% and 15.5% respectively.WYT group also had a tendency to improve skin prick test.Serum IgE level was closely related to specific igE level(P<0.001)in asthmatics.Moreover,the difference of specific IgE between pre-and post-treatment was significantly related to the difference of histamine release between pre-and post-treatment in WYT group(P<0.005). Our previous study has showed that the suppressor T cell function was negatively correlated to the level of serum IgE in asthmatics treated with WYT.So it was suggested that WYT acted on the regulation of immunologically competent cell and in this way it enhanced Ts cell function and inhibited the seasonal increase of IgE.As a result,histamine release was decreased and seasonal attack of bronchial asthma was relieved. |
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