| 李建新,汤化琴,朱晓棣,刘迪,夏蓉西,李竞,徐东琴,冯学瑞.5号祛腐生肌散“生肌”作用的实验研究[J].,1988,(6):355,326- |
| 5号祛腐生肌散“生肌”作用的实验研究 |
| Experimental Research on Promoting Granulation Effect of No.5 Qufu Shengji San |
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| DOI： |
| 中文关键词: 祛腐生肌散 成纤维细胞增殖 肉芽组织 伤口愈合 中西医结合 材料与方法 外科疮疡 新生毛细血管 巨噬细胞 临床观察 |
| 英文关键词: |
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| 中文摘要: |
| 5号祛腐生肌散是天津市中西医结合外科疮疡研究所治疗体表溃疡常用的五种散剂之一,经多年临床观察,对疮疡溃后、脓腐已净之溃疡,确有加速伤口愈合的作用。愈合后的瘢痕多呈线型,很少发生瘢痕挛缩。为探其机理,我们进行了以下工作。材料与方法健康成年雄性大白鼠32只,体重180±25g,常规饲养1周后随机分为两组。将珍珠 |
| 英文摘要: |
| No.5 Qufu Shengji San(QFSJS)is one of the five powders for the common use of treatment according to the principle of eliminating the putrefied tissue and promoting the granulation in treating the superficial ulcers.It consists of Concha Margaritifera usta,Elephas africanus,Crinis carbonisatus Calamine,Daemonorops draco,Acacia catecha,Gypsum fibrosum and Borneolum synthelicum.After mixing they were ground into fine powder.In clinical practice it was used in the repairing phase of the superficial ulcer after the ulceration and exhaustion of the necrotic tissue and pus.Clinical observation for several years revealed that this remedy could accelerate the healing of superficial ulcer.In order to study the mechanism of promoting granulation effect,the weight of granulation tissue was measured after applying this medical dressing typically on the superficial ulcer of experimental rats,and histological examination was also made.The result showed the weight of the newly grown granulation tissue of the experimental group was heavier than that of the control animal.Histological examination revealed that the granulation tissue of the experimental group had three characteristics:(1)Their capillaries were abundant,the caliber larger and the wall of the capillaries thinner;(2)There were more macrophages in every growing stage;(3)There were more fibrocytes with the phenomenon of karyokinesis in the initial stage, The result of the experiment indicated that the promoting granulation effect of No.5 QFSJS was correlated to the following three factors:(1)Promoting the proliferation and differentiation of the cell;(2)Promoting the wandering out of macrophages;(3)Improving the local blood circulation, accelerating the metabolism of the wound surface. |
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