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Author Name	Affiliation
Zhang Yuwu	西安医科大学第一附属医院
Xue Ying	西安医科大学第一附属医院
Zhang Bingqian	西安医科大学第一附属医院

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中文摘要:

对35例恶性淋巴瘤患者分组治疗,结果表明丹参对 COP 治疗方案有增效作用。血浆纤维蛋白原(Fg)测定显示恶性淋巴瘤患者组较正常对照组高(P<0.01)。COP方案治疗组疗后血浆 Fg 较疗前有所降低(P>0.5);丹参—COP 方案治疗组血浆 Fg 疗后较疗前明显降低(P<0.01)。血浆 Fg 含量与疗效呈负相关。提示丹参的促纤溶作用是其抗肿瘤作用的重要机制之一。

英文摘要:

35 cases of malignant lymphoma were divided into two groups randomly,22 cases of which were treated with Salvia miltiorrhiza(SM)-COP therapy,and only 13 cases by COP therapy.In terms o’f short-term effect,it has been found that SM-COP therapy was more effective than COP therapy,P< 0.01.The experimental study showed that one of the mechanisms of SM against tumor is improving the hypercoagulation state through lowering the serum hyperfibrinogen,from 3.626±1.638 to 2.343± 0.576 mg/dl,P<0.01,which is significant in showing that promoting the fibrinolytic activity was closely related with the therapeutic effect,and was one of the antitumor mechanisms.

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