欢迎访问中国中西医结合杂志！

旧版登录

Chinese Version

Online office

Journal Online

Forthcoming Articles >>

Current Issue >>

Next Issue >>

Earlier Issues >>

Download

Top

Top Downloaded
Top Cited

Links

杨守业,何民,钟永,皮晓霞.半夏对小鼠骨髓嗜多染红细胞微核及人体外周血培养淋巴细胞SCE频率的影响[J].,1990,(6):356-358,326

半夏对小鼠骨髓嗜多染红细胞微核及人体外周血培养淋巴细胞SCE频率的影响

The Influence of Rhizoma Pinelliae on the Occurrences of Micronucleus of Bone Marrow PCE in Mice and Frequencies of SCE in Cultural Lymphocytes of Human

DOI：

中文关键词: 半夏 DBA/2小鼠微核姊妹染色单体交换

英文关键词:

基金项目:国家自然科学基金

Author Name	Affiliation
杨守业	中国中医研究院中药研究所
何民	中国中医研究院中药研究所
钟永	四川大学生物系
皮晓霞	北京中医学院中药系

Hits: 1280

Download times: 952

中文摘要:

半夏的妊娠禁忌作用在妊娠大白鼠、小白鼠和家兔试验中得到证实,半夏汤剂在对母体无害的情况下,具有显著的胚胎毒性。本实验观察了半夏诱发的小鼠骨髓嗜多染红细胞(PCE)微核出现率,结果表明半夏汤剂不引起微核率升高;人体外周血培养淋巴细胞姐妹染色单体交换(SCE)试验表明,半夏汤剂除相当于临床用量的150倍直接加入培养液,引起 SCE 频率显著增高外,其他中低剂量组均不能肯定升高,表明半夏汤剂对 DNA的损伤和修复过程影响不大。提示半夏汤剂不大可能出现遗传毒性。

英文摘要:

Contradictory effects of Rhizoma Pinelliae have been reported in pregnant mice,rats and rabbits,because the decoction of Rhizoma Pinelliae has obvious embryotoxicity.This paper was obtain an experimental analysis of the frequencies of micronucleus of bone marrow polychromatic erythrocytes (PCE) in mice and sister chromatid exchange (SCE) in cultural lymphocytes of human. The results showed that the decoction of Rhizoma Pinelliae neither induces the occurrencies of micronucleus nor SCE frequencies.Therefore,it may be concluded that the decoction does not have toxicogenetical effects.

View Full Text View/Add Comment Download reader