| 张介玉,张庆怡,朱明德,沈惠风,吴志英.慢性肾盂肾炎患者机体免疫功能的研究[J].,1990,(7):402-403,388 |
| 慢性肾盂肾炎患者机体免疫功能的研究 |
| Cell-Mediated Immunity in Chronic Pyelonephritis |
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| DOI： |
| 中文关键词: 慢性肾盂肾炎 细胞介导免疫 至灵胶囊 转移因子 |
| 英文关键词: |
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| 中文摘要: |
| 本文报道用单克隆抗体和间接免疫荧光技术,对30例慢性肾孟肾炎患者和36例健康志愿者外周血 T 细胞亚群的检测。发现慢性肾盂肾炎患者存在着细胞介导免疫功能紊乱。用至灵胶囊或转移因子并结合各种抗生素治疗3月后,患者细胞介导免疫功能和临床症状明显改善。认为外周血 CD4/CD8比例降低是肾功能正常的慢性肾盂肾炎患者免疫学改变的一个标志,可能与疾病复发有关;用至灵胶囊或转移因子并结合各种抗生素治疗较单用抗生素或清热解毒药效果更理想。 |
| 英文摘要: |
| The authors used monoclonal antibody （CD3,CD4,CD8） and indirect immunofluorescence technic to study peripheral blood lymphocyte surface markers in patients with chronic pylonephritis （CPN） and in normal controls.In CPN patients,a significant decrease in CD3,a lower percentage of CD4 and significant higher persentage of CD8 leading to a derease in the CD4/CD8 ratio were noted.No differences could be observed between Spleen-Kidney Yang （阳） deficiency and Kidney Yin （阴） defi- ciency.The overall picture shown by the CPN patients was compatible to a cell-mediated immune response defection.The CPN patients were then treated with Zi-Ling capsule.（至灵胶囊,ZLC）/ transfer factor （TF） and various antibiotics for three months,during which period the authors found a significant increase in CD3,CD4,but no significant change in CD8.Symptoms such as lumbago, fatigue,frequency of urination were improved.A significant decreased in CD4 after cessation of treatment with ZLC and TF was observed.These observations suggested that both ZLC and TF could also improve the immune function,however,they mainly affect CD4 but not CD8 cells,and the effect lasted for only a short period.In conclusion,ZLC/TF and antibiotics administered together would serve as a useful therapeutic measure to be recommended for patients with CPN. |
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