路桂荣,廖静,李延钧,刘伟莉,武纯净,李赤,鄂征.紫草萘醌单体分离物的抗癌生物效应测试[J].,1990,(7):422-425,390 |
紫草萘醌单体分离物的抗癌生物效应测试 |
The Detection of Anti-Cancer Biological Effect of Naphthoquinone Pigment-LⅢ |
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DOI: |
中文关键词: 紫草荼醌单体-LⅢ 癌细胞系 抗癌生物效应 |
英文关键词: |
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中文摘要: |
紫草萘醌单体分离物-LⅢ(简称紫草素),是从中草药紫草中提纯的一种新的有效成份。本实验应用多项指标,检测了紫草素对人胃癌和人食管癌来源的两种细胞系的抗癌生物效应。实验显示:在紫草素剂量为3~5μg/ml 的条件下,癌细胞的生长曲线、分裂指数均受抑制,而人来源的正常细胞未见明显影响;在剂量为5~10μg/ml 情况下,癌细胞的集落形成率受到抑制。紫草素的抗癌生物学效应可能与它降低癌细胞 RNA 含量以及对癌细胞超微结构的影响有关。 |
英文摘要: |
Naphthoquinone pigment-LⅢ,an extract from Arnebia euchroma,could apparently inhibit the proliferation of stomach cancer cell line and esophagus cancer cell line At the effective concentra- tion of 5μg/ml,the mitotic index and growth curve declined without showing any damage to human normal cells.At 5~10μg/ml,the colony efficiency of cancer cells became significantly low.The anti-cancer effect of Naphthoquinone pigment-LⅢ might be related to its role of influencing the amount of RNA and ultrastructure of cancer cells which was discussed in this paper. |
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