| 王友群,韦健全,戴德哉.肠粘康对大鼠实验性肠粘连的预防作用[J].,1991,(8):484-485,454 |
| 肠粘康对大鼠实验性肠粘连的预防作用 |
| Preventive Effect of Changzhankang in Experimental Intestinal Adhesions of Rats |
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| DOI： |
| 中文关键词: 肠粘康 布洛芬 肠粘连 |
| 英文关键词:Changzhankang ibuprofen intestinal adhesions rats |
| 基金项目: |
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| 中文摘要: |
| 手术损伤回肠末段造成大鼠实验性肠粘连,以等级记分法评价肠粘连程度。手术对照组全部出现较严重的肠粘连。肠粘康浸膏20g/kg 灌胃,每天1或2次,连续5天,显著减轻肠粘连的严重程度,并有部分大鼠完全不出现肠粘连,与手术对照组相比有显著差异(P<0.01和 P<0.05)。结果表明肠粘康具有较好的抗肠粘连作用。 |
| 英文摘要: |
| Intestinal adhesions were induced in rats by stabbing the terminal part of the ileum.Adhesion prevention by ibuprofen and Changzhankang(CZK),which was composed by traditional Chinese medicines,was evaluated with a grading system.All of the 13 rats in the non-treated group created severe-adhesions.The severity was significantly modified by orally administered CZK of 20 g/kg (in crude drugs)once or twice daily for five days (P<0.01 and P<0.05 compared with the non-treated).Intramuscular injection of ibuprofen (35 mg/kg,3 times daily)also alleviated the severity of adhesions.There was no significant difference between the ibuprofen-treated and CZK-treated groups though some of the rats were virtually free from adhesion formation in the latter.It is plausible to expect CZK to become a promising drug used in treating intestinal adhesions, for the natural drug has greater security and less side effects than synthesized drugs. |
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