| 丁洁,吴咸中,薛小平.脾虚证患者部分细胞和局部免疫功能指标的测定[J].,1992,(2):77-79,67,68 |
| 脾虚证患者部分细胞和局部免疫功能指标的测定 |
| Determination of Partially Cellular and Local Immune Function in Patients with Spleen Deficiency Syndrome |
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| DOI： |
| 中文关键词: 脾虚 OKT单克隆抗体 白细胞介素2 分泌型免疫球蛋白A |
| 英文关键词:Spleen deficiency syndrome OKT System monoclonal antibody interleukin 2 salivary immunoglobulin A |
| 基金项目: |
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| 中文摘要: |
| 本实验对30例脾虚证和20名正常人的末梢血OKT系统T细胞亚群分类、淋巴细胞体外白细胞介素2(IL2)的分泌功能及局部免疫功能——唾液中分泌型免疫球蛋白A(SIgA)进行测定。结果:脾虚证患者与正常人相比,末梢血中T淋巴细胞总数(T_总)、辅助性T细胞(T_H)明显减少,抑制性T细胞(T_S)相对增多,T_H与T比值异常,单位淋巴细胞体外分泌IL2功能无明显改变;唾液SIgA水平在酸刺激前明显高于正常人,负荷实验储备力降低。说明脾虚证患者细胞免疫功能降低,免疫调节机制紊乱,免疫抑制占优势,消化道局部免疫功能低下。 |
| 英文摘要: |
| The immune function status as reflected by the peripheral blood OKT system T cell subset classification and the lymphocyte in vitro interleukin 2 (IL2) secretory function were determined in 30 patients with Spleen deficiency syndrome and 20 normal subjects in this study. Experimental results decreased cellular immune function and disturbance of immune regulatory mechanism in the patients. Its manifestations were decreased number of total T lymphocytes and helper T cells (Th), relatively increased suppressor T cells (Ts), abnormal rate of Th to Ts, no marked change of IL2 secretory function of T cell in vitro, increased SIgA level before stimulating with acid but marked decreased SIgA level after stimulating. All these suggest the compensatory stage of local immune function. |
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