| 许静亚,杨峻,李乐真,邢素兰,吕丽萍.雷公藤抗肿瘤的实验研究[J].,1992,(3):161-164,134 |
| 雷公藤抗肿瘤的实验研究 |
| Study of Antitumor Effect of Tripterygium wilfordii |
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| DOI： |
| 中文关键词: 雷公藤 抗肿瘤 小鼠 大鼠 |
| 英文关键词:Tripterygium wilfordii antitumor mice rat |
| 基金项目: |
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| 中文摘要: |
| 从雷公藤浸膏中分离得到一个具有明显抗癌活性的新组份。腹腔注射间断给药2～3次能延长小鼠H22、S180、EAC及乳癌荷瘤小鼠的生存期,延长率>100%,P<0.01。口服对小鼠S37瘤重抑制率达42%,P<0.01。对3-MCA碘油溶液支气管内注入诱发的大鼠实验性肺癌,经口服间断给药,瘤重抑制率为65.13%,P<0.05。以10、20μg/ml浓度培养48h时能杀死95%以上的HL60的细胞;以20、40μg/ml浓度培养48h,能杀死90%的Daudi细胞。对离体小鼠腹腔Mφ功能,5.10μg/ml时增强,20μg/ml和以上时则抑制吞噬功能。 |
| 英文摘要: |
| A new component of antitumor action TG has been isolated from the ethyl acetated extract of Tripterygium wilfordii （besides Triptolide, Tripdiolide and Triptonide）. TG was shown in this study to have obvious antitumor effects. The average life span of H22, S180, EAC and breast carcinoma-bearing mice treated wich TG ip×2 days were 100% more than those of the control mice （P<0.01）TG was able to inhibit tumor growth of S37-bearing mice at the dose of 150mg/kg per day, ig×3,its inhibitory rate was 42% （P<0.01）. TG could also inhibit squamous epithelial lung carcinoma induced by 3-methycholanthrene. The inhibitory rate was 65.13% （P<0.05）. TG had remarkable killing effect on human HL60 and Daudi cells and two direction effects on function M（?） of mouse abdominal cavity in vitro. |
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