| 李玮,周楚华,路千里,佘运初.活血通经中药对卵巢和子宫功能的影响及其作用机理[J].,1992,(3):165-168,134 |
| 活血通经中药对卵巢和子宫功能的影响及其作用机理 |
| Effects of Some Chinese Materia Medica in Activating Blood and Stimulating Menstrued Flow on the Endocrine Function of Ovary-Uterus and Its Mechanisms |
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| DOI： |
| 中文关键词: 丹参 川芎 刘寄奴 雌二酯 孕酮 前列腺素 受体 |
| 英文关键词:Salvia miltiorrhiza Ligusticum chuanxiong Artemisia anomale estradiol progesteron prostaglandin receptor |
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| 中文摘要: |
| 在未成年大鼠,丹参能提高血中E2含量,使子宫增重,提高卵巢内PGF2α含量。丹参、川芎、刘寄奴均降低卵巢内PGE2含量;刘寄奴降低子宫雌二醇受体特异结合量;丹参可促进妊马清促性腺素（PMSG）诱发的未成年小鼠排卵。在假孕大鼠,丹参、川芎、刘寄奴均降低血中孕酮含量和抑制卵巢hCG/LH受体特异结合量;刘寄奴还抑制卵巢内源性PGE2生成以及体外培养后PGE2的生成,但促进子宫内源性PGF2α的生成;川芎能提高子宫孕酮受体特异结合量。 |
| 英文摘要: |
| Effects of Salvia miltiorrhiza （SM）, Ligusticum chuanxiong （LC） and Artemisia anomale （AA） on the endocrine function of ovary-uterus were studied. In immature Wistar rats, SM increased the level of estradiol （E2） in plasma （131.8±7.4pg/ml, P<0.01）, the weight of uterus （35.3±4.5mg, P<0.05） and the ovarian PGF2a content （495.0±41.7pg/ova, P<0.05）, but the ovarian PGE2 content was reduced （2198.3±139.0pg/ova, P<0.01）, as compared with that in the control （96.6±3.2pg/ml, 23.3±2.6mg, 339.0±30.0pg/ova. and 3840.8±480.0pg/ova. respectively）. LC and AA had no influence except that they decrease PGE2 content in ovary （2534.8±351.3 and 2629.7±290.7pg/ova）. AA decreased the receptor binding capacity for E2 in uterus （P<0.05）. SM stimulated the ovulation in immature mice pre-treated with PMSG. LC and AA had no significant effect on ovulation. In pseudopregnant rats （with PMSC-hCG）, SM, LC and AA all inhibited the function of corpus luteum, decreased the level of progesterone in plasma （11.1±2.8, 15.5±2.5,19.3±5.6, respectively, 55.4±5.4ng/ml in control, P<0.01） and hCG/LH receptor binding capacity of ovary （P<0.01）. In pseudopregnant animals treated with AA, endogenous PGE2content of ovary （50.2±2.7pg/ml ova.） and the formation of PGE2 form AA in vitro in ovary （1765±166pg/mg ova.） were reduced. The PGF2a content in uterus was increased. LC increased the receptor binding capacity for progesterone in uterus cytosol （P<0.05）. These results showed that SM, LC and AA could affect the endocrine function of ovary-uterus by the same or different mechanism. |
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