| 朱剑亮,刘成,刘平,薛惠明,徐列明,洪嘉禾,方军,李培成,王玉润.桃仁提取液合人工虫草菌丝对肝炎后肝硬化免疫机能异常的调节作用[J].,1992,(4):207-209,195,196 |
| 桃仁提取液合人工虫草菌丝对肝炎后肝硬化免疫机能异常的调节作用 |
| Modulating Effects of Extractum Semen Persicae and Cultivated Cordyceps Hyphae on Immuno-Dysfunction of Inpatients with Posthepatitic Cirrhosis |
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| DOI： |
| 中文关键词: 桃仁提取液 人工虫草菌丝 肝炎后肝硬化 细胞免疫 体液免疫 |
| 英文关键词:posthepatitic cirrhosis Extractum Semen Persicae Cordyceps Hyphae cellular immune function humoral immune function |
| 基金项目: |
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| 中文摘要: |
| 本文结果表明桃仁提取液合人工虫草菌丝对肝炎后肝硬化异常的免疫机能具有良好的调节作用。经治疗后能提高患者淋巴细胞转化率、周围血中CD3+与CD4+百分率、NK细胞活性以及血清补体C3、C4水平;降低血清中IgG、IgA、SSIgA含量;并能促进血中CIC的消除。 |
| 英文摘要: |
| The treatment of 65 cases （with 20 cases in the control group） of patients with posthepatiticcirrhosis by Extractum Semen Persicae （ESP） and cultivated Cordyceps Hyphae （CH） was reported,and the adjustment of the disorders of both cellular and humoral immune functions was investigated.The results indicated apparently that the restrained cellular immune function, among which the rateof lymphocyte transformation, the NK cell’s function, CD8+and CD4 cells in the patients group werelower than those in the healthy group. The CD8+cell count was positively correlated with lymphocytetransformation rate and the humoral immune hyperfunction revealing that the levels of IgG, IgA,ssIgA and CIC of the patients were abnormally higher than those of healthy subjects, while level ofC3 was negatively correlated with that of CIC. After the treatment, rate of transformation, functionof NK cell, CD8+, CD4+cells, and the ratio of CD4+/CD8+ improved; levels of IgG, IgA, ssIgA and CICreduced, while those of C nd C3 rose. These results revealed the ESP and cultivated CH couldmodulate the cellular immune function,.inhibit the humoral immune hyperfunction and increaseserum complement level in patients with posthepatitic cirrhosis, which were correlated to theimprovement of hepatic function. Disorder of immune function was one of the important causes ofliver cell necrosis, inflammatory cell infiltration and fibroplastic proliferation. The results showedthat the drugs are of some value in the treatment of patients with posthepatitic cirrhosis. |
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