| 涂胜豪,李鸣真,叶望云.热毒清抗内毒素性DIC所致肝细胞微粒体损伤的实验研究[J].,1992,(4):226-227,198 |
| 热毒清抗内毒素性DIC所致肝细胞微粒体损伤的实验研究 |
| The Antagonistic Effect of Re Du Qing on Damage of Hepatocytic Microsomes in Rabbits with Endotoxin-Induced DIC |
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| DOI： |
| 中文关键词: 微粒体 脂质过氧化 细胞色素P—450 苯胺羟化酶 |
| 英文关键词:microsome lipid peroxide cytochrome P-450 endotoxin DIC aniline hydroxylase |
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| 中文摘要: |
| 本实验采用家兔静脉注射内毒素制作DIC模型,观察中药制剂"热毒清"对内毒素性DIC所致肝细胞微粒体损伤的影响。结果表明:热毒清能减轻细胞色素P-450含量和苯胺羟化酶活性降低程度,降低DIC病理过程中微粒体内脂质过氧化水平。整体相关分析表明:微粒体内脂质过氧化水平与上述两种酶活性间均呈明显负相关。提示热毒清具有拮抗内毒素性DIC所致微粒体损伤的作用,而减轻微粒体膜的过氧化损伤,可能是其保护微粒体功能的机制之一。 |
| 英文摘要: |
| In this study, the generalized Schwartzman reaction of rabbit induced by endotoxin of Escheri-chia Coli was built as DIC models. The experiment showed that the levels of lipid peroxide (LPO)in the hepatocytic microsomes of model group were increased significantly, whereas the cytochromeP-450 (Cyto. P-450) contents and aniline hydroxylase activities were obviously decreased. In the ReDu Qing (RDQ) group and dexamethasone group the decrease of LPO in hepatocytic microsomes aswell as the reduction of Cyto. P-450 contents and aniline hydroxylase activities were alleviated.Furthermore, the correlation analysis indicated a significant negative correlation between levels ofLPO in microsomes and the Cyto. P-450 contents as well as aniline hydroxylase activities. This studyindicates the LPO may play an important role in the damage of hepatocytic microsomes and RDQcould prevent hepatocytic microsomes from injury of rabbits with endotoxin-induced DIC. |
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