| 谢恬,凌一揆.清瘟败毒饮对内毒素诱发家兔温病气血两燔证的疗效和机理[J].,1993,(2):94-97,69 |
| 清瘟败毒饮对内毒素诱发家兔温病气血两燔证的疗效和机理 |
| Studies on the Herbal Decoction of Qingwen Baidu Yin in Treating Endotoxic Fever of Rabbits |
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| 中文关键词: 清瘟败毒饮 内毒素 家兔气血两燔证 |
| 英文关键词:Qingwen Baidu Yin endotoxic fever |
| 基金项目: |
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| 中文摘要: |
| 采用内毒素诱发家兔温病气血两燔证模型,观察了清瘟败毒饮对此模型的疗效,初步阐明了该方的药理作用及机理。实验结果表明该方具有以下作用:（1）对发热具有明显的抑制作用,与对照组相比,平均发热曲线降低,最大发热高度均数（△T）较小,体温反应指数（TRI5）也较小,P<0.001。（2）能改善家兔注射内毒素后白细胞里先降低后升高现象,并能拮抗血小板降低。（3）能拮抗高粘综合征（血瘀）,具有解聚、降粘、稀释血液（凉血化瘀）作用。（4）该方抑制家兔气血两燔证发热效应同时,使血浆中升高的cAMP降低,下降的cGMP升高,具有调整cAMP、cGMP比值的作用。这一结果为阐明"阳盛则热","阳胜则阴病"的本质提供了线索。（5）病理形态学表明,该方具有保护内脏器官、减轻脏器组织病理损害的作用。 |
| 英文摘要: |
| Qingwen Baidu Yin （QBY） has good curative effects on the endotoxic fever of rabbits inducedby injecting endotoxin of E. Coli. The test group was given QBY orally, while the control group wasgiven NS orally instead. Result showed QBY could: （1） Markedly inhibit the fever, it was effectivein reducing febrile curve. △T and TRI5, of the test group were smaller （P<0.001）. （2） Ameliorate theleukocytopenia and leukocytosis, and improve thrombocytopenia. （3） Antagonize hyperviscositysyndrome and had the actions of depolymerization and dilution. （4） In test group, the increased cAMPcontent in plasma was reduced, and the decreased cGMP content raised, the ratio of cAMP andcGMP was nearly normal. All these provided the clue in elucidating the essense of "Excessive Yangcauses Heat" and "Predominance of Yang leads to disorder of Yin". （5） Pathomorphological examina-tion showed that QBY had the functions ot protecting the internal organs and reducing the organicdamage induced by endotoxing in rabbits. |
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