| 傅春景,赵根尚,张建芳,李光泽.川芎嗪对离体大鼠心肌缺血再灌注损伤的影响[J].,1993,(4):228-229,198 |
| 川芎嗪对离体大鼠心肌缺血再灌注损伤的影响 |
| Effect of Ligustrazine on Isolated Myocardial Ischemic Reperfusion Injury in Rats |
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| DOI： |
| 中文关键词: 川芎嗪 大鼠 心肌 再灌注损伤 血栓素 |
| 英文关键词:ligustrazine myocardium reperfusion injury thromboxane B2 |
| 基金项目: |
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| 中文摘要: |
| 本实验用改良的langendorff模型灌流离体大鼠心脏,探讨心肌细胞本身或血管内皮细胞,是否在缺血再灌注时也参与了血栓素A2（TXA2）的释放,并探讨川芎嗪对TXA2的影响。结果显示心肌缺血后再灌注时冠脉回流液中TXB2含量增多,6-酮-前列腺素F1α(6-keto-PGF1α)相对减少,TXB2/6-keto-PGF1α比值增高,乳酸脱氢酶（LDH）释放增多。说明川芎嗪能促进6-keto-PGF1α的产生,且能够抑制TXB2和LDH的释放。 |
| 英文摘要: |
| In recent years, it is believed by some scholars that the injury of myocardial ischemic reperfusionis correlated to the thromboxane A2（TXA2） released by platelets. In order to explore that whetherthe myocardial and hemangio-endothelial cells participate in the TXA2 production during the processof reperfusion, the modified Langendorff method was used to establish the model of reperfusing theisolated rat heart. On the other hand, this experiment was also intended to observe the effect ofligustrazine on the injury of myocardial ischemic reperfusion. The results revealed that the level ofthromboxane B2 （metabolite of TXA2） and lactic dehydrogenase （LDH） in coronary sinus refluxfluid increased during the process of reperfusion, while the level of 6-keto-PGF1α in the same fluidrelatively decreased （P<0.05）. The ratio of TXB2/6-keto-PGF1α was raised. The ligustrazineinhibited the release of TXB2 and LDH, but promoted the production of 6-keto-PGF1α （P<0.05）. Theresults also proved that the myocardial and hemangio-endothelial cells could synthesize TXA2, andthe amount of TXA2 released increased during the reperfusion of ischemic myocardium, which waslikely to be the major factor of the injury of ischemic myocardial reperfusion. Ligustrazine playsan important role in protecting the myocardium. |
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