| 金益强,黎杏群,胡随瑜,刘爱平,易振佳,李家邦,梁清华,陈泽奇,张自强,张翔,李学文,朱崇学,陈昌华,王勇华.肝风内动证三亚型的病理生理学基础研究[J].,1993,(7):391-396,387 |
| 肝风内动证三亚型的病理生理学基础研究 |
| Study on Pathophysiological Basis of 3 Subtypes in Ganfeng Neidong Syndrome |
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| DOI： |
| 中文关键词: 肝风内动证 肝阳化风证 血虚生风证 阴虚风动证 病理生理学基础 |
| 英文关键词:Ganfeng Neidong Syndrome Ganyang Huafeng Syndrome Xuexu Shengfeng Syndrome Yinxu Fengdong Syndrome pathophysiological basis |
| 基金项目:国家自然科学基金 |
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| 中文摘要: |
| 本研究首次对肝风内动证三类亚型(肝阳化风、血虚生风、阴虚风动)进行不同层次多指标实验研究,发现肝阳化风证有:脑供血障碍和脑组织损伤表现;机体处于应激状态;调节血管平滑肌舒缩功能活性物质含量显著变化。血虚生风、阴虚风动证各类指标测定值相近,异常程度较轻。 |
| 英文摘要: |
| The multiple parameters of 3 Subtypes: Ganyang Huafeng Syndrome GYHFS), XuexuShengfeng Syndrome and Yinxu Fengdong Syndrome of Ganfeng NeidongSyndrome were determined for the 1st time. It was found that there were several characteris-tics in GYHFS. （1） Disturbance of the cerebral blood flow and the damage of brain tissue wasmanifested by the abnormality of the bulbar conjunctival microcirculation, carotid Doppler ultra-sonic determination and brainstem auditory and visual pathway, high blood viscosity, dysmnesia,free radical and lipid peroxidation injury and the changes of Zn, Cu, K and Mg after brain damage.（2） Stress status were expressed by the high plasma levels of cortisol, norepinephrine and epine-phrine, decreased serum triiodothyronine level and hyperfunction of sympathetic nerve. （3）Themarked changes of the regulating substance of the vessel smooth muscle function including theincreased plasma levels of TXB2, TXB2/6-k-PGF1α, and calmodulin, as well as decreased SP, ANP,CGRP. Other 2 subtypes had about the same changes of these parameters, but of milder disorders. |
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