| 黄艳红,叶雪清.补肾中药片对围绝经期妇女骨质疏松代谢的影响[J].,1993,(9):522-524,515 |
| 补肾中药片对围绝经期妇女骨质疏松代谢的影响 |
| Clinical Study on Bone Metabolism and Chinese Medicinal Treatment of Menopausal Osteoporosis |
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| DOI： |
| 中文关键词: 绝经 骨质疏松 雌酮 雌二醇 钙 骨密度 补肾中药片 己烯雌酚 |
| 英文关键词:menopause osteoporosis estrogen Chinese medicinal herbs |
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| 中文摘要: |
| 为探讨围绝经期骨质疏松的发生及中西药物的防治作用,对48例围绝经期妇女测定了血清雌酮（Eo）、雌二醇（E2）、钙（Ca）、磷（P）、碱性磷酸酶（ALP）和空腹尿Ca/肌酐（Cr）比值,以及右侧桡骨骨密度（DMD）值。又将绝经后妇女随机分为补肾中药片治疗组和己烯雌酚治疗组,进行治疗前后自身对照研究。结果表明:绝经后血清Eo、E2及桡骨BMD值显著降低,血清Ca、ALP及空腹尿Ca/Cr比值升高。补肾中药片治疗组使血清Eo下降E2升高,己烯雌酚治疗组使血清ALP及空腹尿Ca/Cr比值下降。提示:雌激素缺乏是引起绝经后妇女骨质疏松的主要原因,补肾中药片具有预防和治疗骨质疏松的作用,己烯雌酚具有预防作用,而无治疗作用。 |
| 英文摘要: |
| 48 perimenopausal women were divided into premenopausal （PrM） and postmenopausal （PoM）groups, which were sub-divided into Chinese medicinal herbs （CM） and DES treatment groups, and 12 middle aged women were served as control. E0, E2, T, GH, Ca, P and ALP in the serum and the ratio of Ca/Cr in fasting urine as well as the BMD of right radius was measured. Results showed The E0, E2 of the PoM were significantly lower than those of the PrM and control groups （P<0.05, P<0.01）, with no remarkable difference in GH; the T value of PoM was lower than that ofcontrol （P<0.01）. Serum Ca and ALP and the ratio of Ca/Cr in fasting urine of the PoM were much higher than those of the control （P<0.01）; the serum Ca and urinary Ca/Cr of the PrM were higher than those of the control （P<0.05, P<0.01 respectively）. The BMD value of the radius of both PoM and PrM groups were much lower than that of control （P<0.01）, the BMD of the PoM was lower than that of PrM （P<0.01）. The BMD value of the PoM treated with CM for one month rose significantly （P<0.05）, the serum E0 reduced （P<0.05）, E2 and the serum P rose （P<0.05）, there were no remarkable differences in serum Ca, ALP and urinary Ca/Cr ratio; In group taken DES, the serum ALP and the ratio of urinary Ca/Cr significantly dropped （P<0.01） and no striking differ-ences in radius BMD value and serum GH, E0, E2, and T. Therefore estrogen deficiency was the primary cause of PoM osteoporosis. Serum ALP and the a/Cr ratio in fasting urine could serve as the indexes for early prediagnosis of osteoporosis. Besides, CM could prevent and cure osteopor-osis while DES could prevent but not cure osteoporosis. |
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