| 邹爱民,房敬燕,叶丹,周苏文.黄芫花乙醇对早期孕妇血浆和蜕膜中雌激素、前列腺素和孕酮受体含量的影响[J].,1993,(9):531-532,516 |
| 黄芫花乙醇对早期孕妇血浆和蜕膜中雌激素、前列腺素和孕酮受体含量的影响 |
| Effect of Yellow Daphne on Levels of Plasma and Decidual Eatradiol, Prostaglandins,Progesterone and Its Receptor in Early Pregnancy |
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| DOI： |
| 中文关键词: 黄芫花乙醇 雌二醇 孕酮 前列腺素 孕酮受体 蜕膜组织 |
| 英文关键词:Yellow Daphne steroid hormones prostaglandins progesterone receptor decidual |
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| 中文摘要: |
| 本研究观察了使用黄芫花乙醇注射液抗早孕时,孕妇外周血中雌二醇（E2）、孕酮（P）、前列腺素（PGE2）、前列腺素F2α(PGF2α)含量与蜕膜组织中PGE2及PGF2α和孕酮受体（PR）含量的变化。结果表明黄芫花乙醇注射液可使蜕膜组织变性、坏死,同时使其PGE2、PGF2α含量增加,PR含量降低,而外用血中PGE2、PGF2α含量不变,E2、P含量减少。提示:黄芫花乙醇注射液抗早孕的主要环节可能是使蜕膜变性、释放前列腺素,从而干扰维持早孕的因素,达到终止妊娠目的。 |
| 英文摘要: |
| The changes of plasma concentration of estradiol （E2）, progesterone （P） and prostaglandins （PG）and decidual level of prostaglandins and progesterone receptor （PR） after injection of Yellow Daphne for induction of abortion were observed. The results showed that the treatment with Yellow Daphne could induce degeneration and necrosis of decidual tissues as well as increase of PGE2 and PGF2α concentration with lowering of PR level in the tissue. On the other hand, plasma level of PGE2and PGF2α remained nchanged and the levels of E2 and P declined. The data suggested that the contragestive mechanism of Yellow Daphne was mainly the involvement of decidual degeneration and the release of PG thus interfered the intrauterine environment for maintenance of pregnancy which subsequently led to abortion. |
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