| 刘和娣,李恩,佟晓旭.补肾方药对地塞米松诱发的骨质疏松大鼠体内雌激素和1,25羟维生素D3的影响[J].,1993,(9):544-545,518 |
| 补肾方药对地塞米松诱发的骨质疏松大鼠体内雌激素和1,25羟维生素D3的影响 |
| Effects of Replenishing Kidney Herbs on Estrogen and 1,25-（OH）2-D3 of Dexamethasone-induced Rats Model with Osteoporosis |
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| DOI： |
| 中文关键词: 骨质疏松 雌二醇 钙剂 1,25羟维生素D3 |
| 英文关键词:osteoporosis calcium estrogen 1,25-（OH）2-D3 |
| 基金项目: |
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| 中文摘要: |
| 本实验应用地塞米松（0.1mg/100g体重,2次/周,连续5周）,同时给予低钙饲料,诱发大鼠发生骨质疏松,观察血中雌二醇（E2）,1,25羟维生素D3 [1,25-（OH）2D3]的变化,并给予钙剂、中药治疗,以研究E2、1,25-（OH）2D3和骨质疏松发生的关系及相互影响。结果提示:骨质疏松大鼠体内E2、1,25-（OH）2D3水平均较低（P<0.01、0.05）。通过补肾方药或钙剂治疗后,骨质疏松明显改善,E2、1,25-（OH）2D3得到回升,提示E2、1,25-（OH）2D3的降低和骨质疏松密切相关,可能首发E2降低,继发1,25-（OH）2D3降低。中医补肾方药能影响E2、1,25-（OH）D3的代谢,治疗骨质疏松。 |
| 英文摘要: |
| Estrogen and 1, 25-（OH）2-D3 change in rats with osteoporosis induced by dexamethasone （DXM）was observed. The calcium and replenishing Kidney Herbs （RKH） was used in treating osteoporosis.The results shown: The level of estrogen and 1, 25-（OH）2-D3 in rats with osteoporosis was lower than that of the normal. Calcium and RKH were effective in treating osteoporosis and they could recover the level of estrogen and 1, 25-（OH）2-D3 to normal state, the effect of RKH was better than that of calcium. There was positive correlation between the level of estrogen and 1, 25-（OH）2-D3. The treatment of RKH might be an optimal method for osteoporotic treatment. |
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