| 胡卫列,马永江,郑家富,吴焕.川芎对急性肾功能衰竭家兔血浆TXB2、6-Keto-PGF1α含量影响[J].,1993,(9):549-550,518 |
| 川芎对急性肾功能衰竭家兔血浆TXB2、6-Keto-PGF1α含量影响 |
| Effect of Glycerol-Induced Acute Renal Failure in Rabbit with Ligusticum Wallichii on TXB2,6-keto-PGF1α and 6-keto-PGF1α/TXB3 |
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| DOI： |
| 中文关键词: 急性肾功能衰竭 川芎 血栓素B2 6—Keto—PGF1α |
| 英文关键词:Ligusticum wallichii acute renal failure TXB2 6-keto-PGF1α |
| 基金项目: |
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| 中文摘要: |
| 本研究应用放射免疫测定法分别测定了甘油致家兔急性肾功能衰竭（ARF）后24、48、72h血浆中TXB2、6-Keto-PGF1α及6-Keto-PGF1α/TXB2比值,发现ARF后血浆TXB2的含量显著升高（P<0.01）,6-Keto-PGF1α的含量无明显变化（P>0.05）,6-Keto-PGF1α/TXB2比值显著下降（P<0.01）。应用活血化瘀中药川芎防治ARF能降低血浆中TXB2含量,使血浆中6-Keto-PGF1α的含量略有升高,6-Keto-PGF1α/TXB2比值保持在正常水平,提示川芎能够有效地抑制肾缺血后体内血小板的激活,纠正循环血中PGI2/TXA2平衡失调,对ARF具有积极的防治作用。 |
| 英文摘要: |
| The effect in preventing and treating glycerol-induced acute renal failure （ARF） in rabbit with Ligusticum wallichii （LW） has been studied. 33 male and female rabbits weighing 2.0-3.0 Kg were divided into three groups randomly: （1） LW treated group. （2） pathological control group and （3）normal control group. The measurement of plasma 6-keto-PGF1α, TXB2 concentration and 6-keto-PGF1α/TXB2 ratio were carried out with radioimmunoassay after 24 hr, 48 hr and 72 hr of ARF.The results showed that plasma TXB2 concentration obviously increased （P< 0.01）, 6-keto-PGF1αconcentration had no obvious changes （P> 0.05）, 6-keto-PGF1α/TXB2 ratio markedly decreased and LW could reduce plasma TXB2 concentration, slightly increase the plasma 6-keto-PGF1αconcentration, keep 6-keto-PGF1α/TXB2 ratio in normal level after ARF. It showed that LW could inhibit effectively platelet activation, correct 6-keto-PGF1α/TXB2 imbalance and have a prevent-ing and treating effect for ARK |
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