| 张璧姿,丁锋,陈莉萍,左红,谭立武,彭启舟.乙肝宁冲剂治疗慢性乙型肝炎临床与实验观察[J].,1993,(10):597-599,580 |
| 乙肝宁冲剂治疗慢性乙型肝炎临床与实验观察 |
| Clinical and Experimental Study on Yi-gan-ning Granule in Treating Chronic Hepatitis B |
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| DOI： |
| 中文关键词: 慢性乙型肝炎 乙肝宁冲剂 动物实验 |
| 英文关键词:chronic hepatitis B Yi-gan-ning Granule pharmacodynamics |
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| 中文摘要: |
| 以乙肝宁冲剂治疗慢性乙型肝炎320例,其中68例与齐墩果酸治疗70例临床作对比观察。结果证实:乙肝宁冲剂恢复肝功能的疗效与齐墩果酸相近(P>0.05),而对血清HBV标志物的影响则有明显优势(P<0.05～0.001),62例随访0.5年,其中60例疗效稳定。动物实验表明:乙肝宁冲剂对实验动物肝损伤有明显的保护作用,能促使肝细胞恢复与再生;并有诱生体内干扰素、促进麻鸭HBV血清DNA阴转及改善鸭乙肝肝脏病变的作用。 |
| 英文摘要: |
| This paper reports that 320 patients with chronic hepatitis B （CHB） were treated with Yi-gan-ning Granule （YGNG） and the pharmacodynamics of YGNG in the animal study. As control, another70 patients with CHB recieving oleanolic acid granule （OAG） were compared to 68 patients ill YGNGgroup. YGNG is consisted of Astragalus membranaceus, Artemisia capillaris, Codonopsis pilosula, etal. Each patient has taken YGNG or OAG for 3 months. The result showed YGNG was effective onrecovering the liver function and OAG had similar effect. The sero-negative conversion rates ofHBsAg, HBeAg, HBcAb and positive conversion rate of HBeAb in the YGNG group were 33.1%,40.5%, 10.5% and 15.5% respectively, which were much better than that in OAG group （P< 0.05--0.001）.Theresult of 6 months follow up showed that 60 of 62 patients receiving YGNG were instabilized state. The result in the animal study demonstrated that YGNG had significant protectionfrom the liver damage caused by CCl4. YGNG could decrease serum ALT level and protect the liverfunction of carbohydrate, fat, protein metabolism and detoxication. YGNG could induce interferonin vivo and play an important role in seroconversion of negative DHBV-DNA and improvement ofpathological morphology in viral hepatitis B. |
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