| 杨水祥,洪秀芳,李天德,杨兴生.冠心病血瘀证患者血小板脂质过氧化物与血栓素A2/前列环素平衡的研究[J].,1993,(11):661-662,644 |
| 冠心病血瘀证患者血小板脂质过氧化物与血栓素A2/前列环素平衡的研究 |
| Study on Balance of Lipoperoxidative Damage in Plasma and Platelet with Ratio of TXA2/PGI2 in Blood Stasis Syndrome of CHD Patientt |
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| DOI： |
| 中文关键词: 血瘀证 血小板 脂质过氧化 血栓素 冠心病 |
| 英文关键词:Blood Stasis Syndrome platelet lipoperoxidative damage thromboxane coronary heart disease |
| 基金项目: |
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| 中文摘要: |
| 观察了98名健康人、109例血瘀证和非血瘀证冠心病患者血小板脂质过氧化损伤与血栓素A2/前列环素（TXA2/PGI2）平衡的关系,发现血瘀证组血小板脂质过氧化物（PL-LPO）、血浆脂质过氧化物（LPO）、血栓素B2明显增高,非血瘀证组血小板超氧化物歧化酶（PL-SOD）、血小板硒谷胱甘肽过氧化物酶（PL-SeGSHPx）、血浆超氧化物歧化酶（SOD）、6-酮-前列腺素F1α(6-Keto-PGF1α)显著降低,血瘀证组PL-LPO与血浆LPO呈显著正相关。提示血小板脂质过氧化损伤可能是血瘀证的原发性损伤因素之一;血栓素B2（TXB2）、LPO可能属于血的范畴,PGI2、SOD、SeGSHPx可能属于气的范畴,两者失调则构成本虚标实的病理基础。 |
| 英文摘要: |
| In order to study the biochemical and pathophysiological mechanism of the Blood StasisSyndrome （BSS） or Non-BSS of coronary heart disease （CHD） patients, the activities of SOD,Selenium-glutathion peroxidase, the content of LPO in plasma and platelets and the contents ofTXB2 and 6-keto-PGF1α in plasma were determined in 109 BSS and Non-BSS of CHD patientscompared with 98 healthy controls. It was discovered that the contents of TXB2, LPO, PL-LPO, andthe ratio of TXB2/6-keto-PGF1α were significantly increased in BSS-CHD patients compared withcontrols and Non-BSS-CHD patients. It was also discovered that the SOD activities and thecontents of 6-keto-PGF1α decreased significantly in Non-BSS-CHD patients, The results suggestedthat the injury of platelets by oxygen free radicals might be one of the primary injury factors in BSS-CHD patients. Our conclusion is that PGI2, SOD belong to the catagory of Heart-Qi, while TXA2,LPO to the Blood catagory. Therefore TXB2, 6-keto-PGF1α, SOD, LPO should serve as some ofthe objective indexes for BSS patients of CHD. |
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