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赵元君,陆福年,王元书,李云舫,孔祥生,石敬亭,赵常德.川参通注射治疗前列腺增生症的临床和实验研究[J].,1994,(1):21-23,4
川参通注射治疗前列腺增生症的临床和实验研究
Clinical and Experimental Study of Benign Prostatic Hyperplasia with Intraglandular Injection of Chuan Shen Tong(川参通)
  
DOI:
中文关键词:  川参通  前列腺增生症  尿流率  剩余尿量
英文关键词:Chinese herbal medicine  Chuan Shen Tong  benign prostatic hyperplasia
基金项目:
Author NameAffiliation
Zhao Yuan-jun 济南军区91医院
山东医学科学院药物研究所 
Lu Fu-nian 济南军区91医院
山东医学科学院药物研究所 
王元书 济南军区91医院
山东医学科学院药物研究所 
李云舫 济南军区91医院
山东医学科学院药物研究所 
孔祥生 济南军区91医院
山东医学科学院药物研究所 
石敬亭 济南军区91医院
山东医学科学院药物研究所 
赵常德 济南军区91医院
山东医学科学院药物研究所 
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中文摘要:
      我院用中药川参通注射液注射治疗前列腺增生症1038例,总有效率96%。尿流率峰值和平均值治疗后分别提高18.0%(P>0.05)、41.8%(P<0.01);经腹和直肠超声测量前列腺体积,分别比治疗前缩小0.51cm(P>0.05)、0.40cm(P<0.01);剩余尿量均值减少60.5ml(P<0.01);症状改善,效果满意。动物实验表明,川参通对丙酸睾丸酮所致的小鼠前列腺增生,有明显的治疗作用。病理证实增生的腺体缩小。实验犬的前列腺组织定量分析结果,治疗后主质缩小26.8%、间质缩小4.5%,总体积缩小31.3%。为临床应用川参通注射液治疗前列腺增生症提供了可靠依据。
英文摘要:
      cases of benign prostatic hyperplasia(BPH)were treated by injection of Chuan Shen Tong(CST),a Chinese herbal medicine,into the prostate gland.At the end of treatment the effective rate was 96%.After the treatment the BPH with urodynamic measurement was studied and it was found that the peak flow rate and mean flow rate increased 18% and 41.8% respectively.Transabdominal and transrectal ultrasonographies were used to measure the shrinkage of prostate’s size after the injection treatment to be 0.51 and 0.4 cm(mean diameter)respectively.Animal model of BPH was established by the testosterone propionate.The prostatic weight and prostatic index was measured in mice after the injection of CST,it significantly decreased compared with that of the control (P<0.01).The pathological findings:The hyperplastic papillae disappeared and the body of prostate markedly shrank in size.Experiment dogs has been carried out for the prostate quantitative analysis.The result revealed that the prostate parenchyma and intercellular substance shrank to 26.8% and 4.5% respectively.
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