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Author Name	Affiliation
Fu Hang-yu	中国中医研究院中药研究所
Zhou Ai-xiang	中国中医研究院中药研究所
Guo Shu-ying	中国中医研究院中药研究所

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中文摘要:

桂枝汤能抑制蛙皮素对冷环境中大鼠的降温效应，并不影响等效价蛙皮素及其受体拮抗剂Ｄ－苯丙１２－蛙皮素合并脑室注射引起的体温改变，亦能翻转Ｄ－苯丙１２－蛙皮素在发热大鼠上的升温作用，提示桂枝汤对体温的双向调节，部分通过对下丘脑体温调节中枢中蛙皮素受体的调节起作用。

英文摘要:

Hypothennia induced by adininistration of bombesin into the lateral ventricle of brain in cold exposed rats could be inhibited by Guizhi Tang (GZT).The GZT could also reverse the potency of fever induced by injection of [D-Phe12] bombesin,a bombesin receptor antagonist,into the brain of febrile rats.But there was no effect of GZT on body temperature when bombesin and[D-Phe12] bombesin were simultaneously injected into the lateral ventricle of cold exposed rats.These studies indicated that the dual-directional thermoregulation of GZT was carried out partially by affecting the bombesin receptor in thermoregulation center of hypothalamus.

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