| 汤斌,吴敏毓.TRH与补中益气汤合用对应激小鼠NK活性及内分泌的影响[J].,1994,(2):104-105,70 |
| TRH与补中益气汤合用对应激小鼠NK活性及内分泌的影响 |
| Effect of TRH and Buzhong Yiqi Tang(补中益气汤) on NK Activity and Endocrine in Stress Mice |
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| 中文关键词: 手术应激 促甲状腺激素释放激素 补中益气汤 自然杀伤细胞活性 下丘脑—垂体—甲状腺轴 |
| 英文关键词:stress thyrotropin-releasing hormone Buzhong Yiqi Tang natural killer activity hypothalamic-hapophyseal-thyroi axis |
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| 中文摘要: |
| 本研究促甲状腺激素释放激素（ＴＲＨ）与补中益气汤合用对手术应激小鼠脾脏自然杀伤（ＮＫ）细胞活性及下丘脑—垂体—甲状腺轴激素的影响。小鼠预先应用ＴＲＨ（０．２μｇ／只·ｄ，腹腔注射）和补中益气汤（０．２ｇ／·ｄ，灌服）共３天，末次用药后１ｈ行截肢术，术后２４ｈ取标本检测。发现两药联用，能使下丘脑—垂体—甲状腺轴激素趋于正常水平，并拮抗手术应激对小鼠脾细胞ＮＫ活性的抑制作用，显示出协同效应。 |
| 英文摘要: |
| Both thyrotropin-releasing hormone(TRH) and Buzhong Yiqi tang(BZYQT) were studied on their effect on splenic natural killer(NK) activity and hypothalamic-hypophyseal-thyroid(HHT) axis of stress mice.TRH(0.2μg/mouse/day,ip.) and BZYQT(0.2g/mouse/day,po.) had been glven for 3 days before the amputation of right hind leg of mice were performed.Result showed that the TRH and BZYQT had rarely any effect on splenic NK activity and HHT axis recovery when they were used separately,but when used in combination they could increase the NK activity of splenic cells sigmficantly in comparing with control group(from 8.32-4.50% to 15.60-4.18%,P<0.05),while the HHT axis recovered to normal level at 24 hours after the amputation.The result suggests that there was a synergistic effect between TRH and BZYQT,and which exerted beneficial effect to the HHT axis stabilization and splenic NK activity recovery. |
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